POSTOPERATIVE PAIN MANAGEMENT STRATEGIES AND THEIR IMPACT ON RECOVERY AFTER TOTAL KNEE ARTHROPLASTY .

Postoperative pain management strategies and their impact on Recovery after Total Knee Arthroplasty . - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/09/095459

Enrollment

Registered

2025-09-29

Start date

Unknown

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M172- Bilateral post-traumatic osteoarthritis of knee Health Condition 2: M170- Bilateral primary osteoarthritis of knee Health Condition 3: M173- Unilateral post-traumatic osteoarthritis of knee Health Condition 4: M171- Unilateral primary osteoarthritisof knee

Interventions

Intervention1: MULTI MODAL ANALGESIA (NSAIDs, Acetaminophen, Gabapentinoids, NMDA Antagonits such as Ketamine , Dextromethorphan , immediate-release Opioids,Cognitive therapy, Peri-articular injection

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients 18-80 years undergoing elective total knee arthroplasty. 2.Ability to provide informed consent. 3.No pre-existing chronic pain disorders or opioid dependency. 4.Osteoarthritis/ Senile Osteoarthritis / Early Onset Osteoarthritis/ Traumatic Osteoarthritis

Exclusion criteria

Exclusion criteria: 1.Refusal to participate 2.Revision surgeries. 3.Patients with cognitive impairment or severe comorbidities 4.Tuberculosis Arthritis 5.Post TB Arthritis

Design outcomes

Primary

Measure	Time frame
Multimodal pain management provides superior postoperative recovery outcomes compared to opioid-only and regional anesthesia strategies.Patients receiving multimodal therapy report lower pain scores and faster functional recovery than those managed with opioids alone.Timepoint: 24 hrs	—

Secondary

Measure	Time frame
The optimal strategy for multimodal analgesia in TKA ideally begins before surgery and continues throughout the perioperative period, extending into the post-discharge phase. A combination of oral and intravenous medications including NSAIDs, selective COX-2 inhibitors, corticosteroids, gabapentinoids , acetaminophen, and opioids can be utilised both before and after surgery to control pain effectively. In addition to pharmacological interventions, techniques like peripheral nerve blocks and periarticular local infiltration analgesia are valuable in managing postoperative pain and should be coordinated with the anesthesia team. Nonpharmacological methods, such as cryotherapy and physical therapy, should also be considered as part of the overall pain management plan.Timepoint: 24 hrs	—

Measure

Time frame

The optimal strategy for multimodal analgesia in TKA ideally begins before surgery and continues throughout the perioperative period, extending into the post-discharge phase. A combination of oral and intravenous medications including NSAIDs, selective COX-2 inhibitors, corticosteroids, gabapentinoids , acetaminophen, and opioids can be utilised both before and after surgery to control pain effectively. In addition to pharmacological interventions, techniques like peripheral nerve blocks and periarticular local infiltration analgesia are valuable in managing postoperative pain and should be coordinated with the anesthesia team. Nonpharmacological methods, such as cryotherapy and physical therapy, should also be considered as part of the overall pain management plan.Timepoint: 24 hrs

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Countries

India

Contacts

Public ContactBhushan Patil

Datta Meghe Institute of Medical Science and Research

Bhushann1001@gmail.com9011721049

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026