Health Condition 1: F20- Schizophrenia
Conditions
Interventions
Intervention1: Tab Vitamin C: The interventional group would receive Tab Vitamin C 1000mg per day for 6 weeks along with antipsychotic monotherapy as usual. Serum Ascorbic Acid and Malondialdehyde lev
Sponsors
Central Institute of Psychiatry
Eligibility
Inclusion criteria
Inclusion criteria: 1. Inpatients satisfying the Clinical Description and Diagnostic Requirements CDDR 2022 for ICD 11 criteria of Schizophrenia. 2. Inadequate response i.e., less than 20 percent reduction on PANSS score from the baseline after an adequate trial i.e., at dose within the recommended therapeutic range for at least 4 to 6 weeks of one antipsychotic. 3. Current PANSS score more than 75, PANSS score 75 corresponded to moderately ill according to CGI SCH. 4. Age 18 to 60 years of both sexes. 5. Those who give informed consent for participating in the study.
Exclusion criteria
Exclusion criteria: 1. Any other major co-morbid psychiatric diagnosis and substance dependence excluding nicotine & caffeine. 2. Significant medical or neurological illness including severe cardiovascular, hepatic or renal disease, anemia, history of severe head injury or myopathy or untreated thyroid disease. 3. Any current systemic infection/inflammation. 4. Patients who received ECT in the last 6 months or currently receiving ECT or any other mode of neuromodulation. 5. Pregnancy. 6. Not willing to give written informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Antioxidant effect of Vitamin C 1000 mg per day in reducing serum levels of Malondialdehyde in patients of Schizophrenia as estimated by Immunosorbent Assay (ELISA).Timepoint: baseline, 3 weeks, 6 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement in the symptoms of Schizophrenia as measured by PANSS, SAPS, SANS, MoCA scores and severity of illness measured by CGI-SCH score after receiving Tab. Vitamin C 1000 mg per day.Timepoint: Baseline, 3 weeks, 6 weeks | — |
Countries
India
Contacts
Public ContactDr Alok Pratap
Central Institute of Psychiatry
Outcome results
None listed