A split-mouth study comparing i-PRF with microneedling and low-level laser therapy on postoperative healing after open flap debridement in stage III periodontitis

Comparative evaluation of i-prf with micro-needling and low-level laser application on post operative healing associated with open flap debridement in the treatment of stage iii periodontitis: A split mouth study - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/09/095434

Enrollment

Registered

2025-09-26

Start date

Unknown

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: I- PRF with microneedling: open flap debridement followed by microneedling on inner aspect of flap & injectable platelet rich fibrin application Control Intervention1: Diode laser: open

Eligibility

Inclusion criteria

Inclusion criteria: Systemically healthy individuals. Patients with Stage-III, Grade-A periodontitis Bilateral pockets with probing pocket depth greater than or equal to 6mm involving at least two or three teeth post phase-I therapy.

Exclusion criteria

Exclusion criteria: History of antibiotic therapy within 6months. Uncooperative patients. Poor oral hygiene. Smokers. Pregnant and lactating women.

Design outcomes

Primary

Measure	Time frame
Plaque index Gingival index Timepoint: at baseline, 1 month, 3 months	—

Secondary

Measure	Time frame
Landry wound healing indexTimepoint: 7th day, 14th day, 1 month.;Probing pocket depth, Clinical attachment level, Gingival thicknessTimepoint: baseline & 3 months.	—

Countries

India

Contacts

Public ContactDr K SUNEETHA

Drs. Sudha and Nageswara rao Siddartha institute of dental sciences

tejaswini07n@gmail.com9014726887

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026