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Evaluation of effects of different levels of pressure applied to lungs on brain pressure and chest expansion in obese patients undergoing camera assisted removal of the gall bladder.

Evaluation of the effects of positive end-expiratory pressure of 12 and 15 on intracranial pressure and dynamic lung compliance in obese patients undergoing laparoscopic cholecystectomy under low flow anaesthesia: A randomized controlled trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/09/095391
Enrollment
70
Registered
2025-09-24
Start date
Unknown
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K80-K87- Disorders of gallbladder, biliary tract and pancreas

Interventions

Intervention1: Application of positive end expiratory pressure(PEEP)of 15 cm H2O in other group.: PEEP will be applied 10 minutes after pneumoperitoneum creation. Control Intervention1: Application of

Sponsors

MAMC and Lok Nayak and Associated Hospitals
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Undergoing general anaesthesia for elective laparoscopic cholecystectomy 2) American society of Anaesthesiologists physical status 1-2 3) BMI: 25-40kg/m2

Exclusion criteria

Exclusion criteria: Pre-existing neurological conditions affecting ICP. Severe respiratory, hepatic, cardiovascular or renal dysfunction. Previous history of upper abdominal surgery. Pregnant women. Acute or chronic eye disease. History of intake of medications affecting ICP.

Design outcomes

Primary

MeasureTime frame
1) Intracranial pressure (as measured using Optic Nerve Sheath Diameter) at various defined time points (T0 to T5). 2) Mean dynamic lung compliance at various defined time points (T1 to T4).Timepoint: T0: Baseline values before induction of anaesthesia (in supine position) T1: 5 minutes after securing of airway and initiation of mechanical ventilation (in supine position) T2: 10 minutes after pneumoperitoneum (in reverse Trendelenburg position) T3: 10 minutes after application of PEEP as per group allocation. T4: 5 minutes after desufflation (in supine position, anaesthetised; before awakening) T5: 5 minutes after removal of airway device (in supine position)—

Secondary

MeasureTime frame
Hemodynamic parameters (mean arterial pressure, heart rate, blood oxygen saturation) every 5 minutes from induction till 20 minutes after PEEP application.Timepoint: 0 minutes, 5 minutes, 10 minutes, 15 minutes, 20 minutes, 25 minutes, 30 minutes, 35 minutes, 40 minutes from induction.—

Countries

India

Contacts

Public ContactDR SHUBHAM SANANTA SAHOO

Maulana Azad Medical College

munisha.agarwal@gmail.com9968604216

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026