Comparing Two Doses of Dexmedetomidine with Ropivacaine for Pain Relief after Lower Abdominal Surgery

A Randomized Comparative Study of Analgesic Effect of Addition of Two Different Doses of Dexmedetomidine as an Adjuvant to Intrathecal Hyperbaric Ropivacaine for Infraumbilical Surgery - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/09/095366

Enrollment

Registered

2025-09-24

Start date

Unknown

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Z488- Encounter for other specified postprocedural aftercare

Interventions

Intervention1: Dexmedetomidine 2 mcg with 0.75% hyperbaric ropivacaine: 3.0 ml of 0.75% hyperbaric ropivacaine + 2 mcg dexmedetomidine (diluted in 0.5 ml saline), total volume 3.5 ml intrathecal. otal

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status I & II Weight between 45 70 kg Patients scheduled for elective infraumbilical surgeries under spinal anesthesia

Exclusion criteria

Exclusion criteria: Patient refusal Sepsis or infection at puncture site Severe systemic illness (renal, hepatic, cardiac, respiratory) Raised intracranial tension Coagulopathy Allergy to study drugs Failed spinal block

Design outcomes

Primary

Measure	Time frame
Time to first rescue analgesia. Total number of rescue analgesic doses in first 24 hours.Timepoint: Assessed at regular intervals up to 24 hours postoperatively.	—

Secondary

Measure	Time frame
1. Onset of sensory block. 2. Duration of sensory block. 3. Onset and duration of motor block. 4. Hemodynamic variables(HR, BP, Spo2) 5. Sedation score 6. VAS pain score 7. OutcomeTimepoint: 1. From injection to T10 level. 2. Till regression to S1 dermatome. 3. Assessed intraoperatively and postoperatively. 4. Baseline, every 5min intraop, then hourly for 6 hours. 5. Intraoperative and postoperative(upto 24hrs) 6. 0,2,4,6,12,24 hrs postoperatively. 7. Throughout intraoperative and 24hrs postoperative period.	—

Measure

Time frame

1. Onset of sensory block. 2. Duration of sensory block. 3. Onset and duration of motor block. 4. Hemodynamic variables(HR, BP, Spo2) 5. Sedation score 6. VAS pain score 7. OutcomeTimepoint: 1. From injection to T10 level. 2. Till regression to S1 dermatome. 3. Assessed intraoperatively and postoperatively. 4. Baseline, every 5min intraop, then hourly for 6 hours. 5. Intraoperative and postoperative(upto 24hrs) 6. 0,2,4,6,12,24 hrs postoperatively. 7. Throughout intraoperative and 24hrs postoperative period.

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Countries

India

Contacts

Public ContactPratibha Rathore

Jhalawar Medical College

dr.sakshi29122016@gmail.com07460819259

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026