Skip to content

Effects of adding the drug Dexmedetomidine in the nose to see its effects on heart rate and blood pressure and on the surgical field during transphenoidal pituitary tumour surgery

Effect of Intranasal Dexmedetomidine on Surgical Field and Haemodynamics in Endoscopic Transnasal Transphenoidal Pituitary Surgery: a Comparison of Two Doses - NIL

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/09/095347
Enrollment
75
Registered
2025-09-24
Start date
Unknown
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G968- Other specified disorders of central nervous system

Interventions

Intervention1: Dexmedetomidine intranasal use: comparing Dexmedetomidine 1 mcg/kg versus 2 mcg/kg intranasally effect on intraoperative hemodynamics the relevant dose will be diluted in total volume

Sponsors

Netaji Subhash Chandra Bose Medical College Jabalpur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: adult patients presenting with pituitary tumours ASA class I & II GCS 15

Exclusion criteria

Exclusion criteria: patient refusal previous nasal surgery pregnancy, cardiac comorbidities raised ICP allergy to study drugs

Design outcomes

Primary

MeasureTime frame
to evaluate the quality of endoscopic surgical field visualisation and amount of bleeding during nasal flap resection. to evaluate effects of intraoperative hemodynamicsTimepoint: hemodynamic parameters will be assessed at specific times intraoperatively, before and after scope insertion, during tumour excision, during flap resection, during sphenoid drilling and extubation.

Secondary

MeasureTime frame
to assess requirement of additional anaesthetic agents to assess quality of emergence post surgeryTimepoint: intraoperatively, for duration of surgery time taken for extubation will be noted

Countries

India

Contacts

Public ContactDr Chris Leslie Lemos

Superspeciality Hospital NSCB Medical College Jabalpur

lemoschris24@gmail.com9373278417

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026