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Comparison between expectant vs medical management with OCPs or Misoprostol for clearance of RPOCs of size less than 2.5cm below 20 weeks of period of gestation

Comparative Efficacy of Expectant Management, Oral Contraceptive Pills and Misoprostol for Management of Retained Products of Conception following Miscarriage: A Randomized Controlled Trial - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/09/095303
Enrollment
159
Registered
2025-09-23
Start date
Unknown
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O034- Incomplete spontaneous abortion without complication

Interventions

Intervention1: comparison between expectant management and medical management with OCPs v/s medical management with Misoprostol tablets)of retained products of conception beloy 2.5 cm at 20 weeks or l

Sponsors

DR BR AMBEDKAR STATE INSTITUTE OF MEDICAL SCIENCES MOHALI
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: PREGNANT WOMEN OF AGE 18 TO 45 YEARS Spontaneous/Induced Miscarriage of Intrauterine pregnancy at Gestation Age LESS THAN 20 weeks RPOCs Size 1 Cm To 2.5 Cm

Exclusion criteria

Exclusion criteria: Hemodynamically unstable patients requiring surgical interventions who are actively bleeding. Patient with sepsis( Fever or raised TLC less than or equal to 15k OR Foul smelling discharge) Patients with any coagulopathy disorders Any contraindications of oral contraceptives Any contraindications of Misoprostol Any uncontrolled medical disorder in the patient Any evidence of post molar RPOCs Any scar RPOCs

Design outcomes

Primary

MeasureTime frame
To compare the successful clearance of RPOCs with use of expectant management or OCPs use compared with misoprostol managed following spontaneous or induced miscarriage.( failure being defined as the need for surgical management)Timepoint: within 4-6 weeks of enrolement—

Secondary

MeasureTime frame
1)1. To Compare the side effects of expectant management or OCPs use with misoprostol for clearance of retained products of conception 2)2. To Compare patient perception regarding use of expectant management or OCPs use with misoprostol for clearance of retained products of conceptionTimepoint: within 4-6 weeks of enrolement—

Countries

India

Contacts

Public ContactDR NIDHI GUPTA

Department of obstetrics and gynaecology, DR. B.R. AMBEDKAR STATE INSTITUTE OF MEDICAL SCIENCES, MOHALI

nidhigupta233@gmail.com8558881510

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026