Comparative study of Ropivacaine epidural infusion versus Intravenous Dexmedetomidine infusion for post surgery pain management and vitals of patient in open Urological surgeries

Comparative study of Ropivacaine epidural infusion versus IV Dexmedetomidine infusion for postoperative pain management and hemodynamic stability in open Urological surgeries - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/09/095251

Enrollment

Registered

2025-09-22

Start date

Unknown

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: epidural infusion versus intravenous infusion: Comparision of analgesic and hemodynamic properties Control Intervention1: dexmedetomidine and ropivacaine: Comparision of epidural infusi

Eligibility

Inclusion criteria

Inclusion criteria: 1)ASA physical status 1-3 2)Scheduled for elective open urological surgeries(nephrectomy,pyeloplasty,radical nephrectomy,radical cystectomy) 3)Willing to give informed consent

Exclusion criteria

Exclusion criteria: 1. Patients with known allergy to local anesthetics or dexmedetomidine 2. Contraindications to epidural catheter placement (coagulopathy, infection at insertion site, severe spinal deformity) 3. Severe cardiovascular disease (uncontrolled hypertension, heart block, cardiac failure) 4. Severe hepatic or renal impairment 5. History of chronic pain requiring regular analgesics 6. Psychological disorders that may affect pain assessment 7. Pregnancy or lactation9 8. Unable to comprehend visual analog scale (VAS)

Design outcomes

Primary

Measure	Time frame
Postoperative pain scores using VAS .Timepoint: baseline 2hours 4hours 6hours 12hours 24hours 36hours 48hours	—

Secondary

Measure	Time frame
1. Time to first rescue analgesic requirement. 2. Total consumption of rescue analgesics in the first 48 hours postoperatively. 3. Hemodynamic parameters (heart rate, systolic blood pressure, diastolic blood pressure) at specified intervals. 4. Sedation scores using the Ramsay Sedation Scale. 5. Incidence of adverse effects (hypotension, bradycardia, respiratory depression, nausea, vomiting, pruritus). 6. Patient satisfaction with pain management (assessed on a 5-point Likert scale: 1 = very dissatisfied, 2 = dissatisfied, 3 = neither satisfied nor dissatisfied, 4 = satisfied, 5 = very satisfied). Timepoint: baseline 2 hours 4 hours 6 hours 12 hours 24 hours 36 hours 48 hours	—

Measure

Time frame

1. Time to first rescue analgesic requirement. 2. Total consumption of rescue analgesics in the first 48 hours postoperatively. 3. Hemodynamic parameters (heart rate, systolic blood pressure, diastolic blood pressure) at specified intervals. 4. Sedation scores using the Ramsay Sedation Scale. 5. Incidence of adverse effects (hypotension, bradycardia, respiratory depression, nausea, vomiting, pruritus). 6. Patient satisfaction with pain management (assessed on a 5-point Likert scale: 1 = very dissatisfied, 2 = dissatisfied, 3 = neither satisfied nor dissatisfied, 4 = satisfied, 5 = very satisfied). Timepoint: baseline 2 hours 4 hours 6 hours 12 hours 24 hours 36 hours 48 hours

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Countries

India

Contacts

Public ContactSupreet kaur

Adesh institute of medical science and research

ankush.singla54@gmail.com9814367676

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026