Health Condition 1: K208- Other esophagitis
Conditions
Interventions
Intervention1: Vonoprazan: Vonoprazan 20mg tablet give once daily orally for duration of 8 weeks.
Control Intervention1: Pantoprazole: Pantoprazole 40mg tablet once daily before breakfast for duration
Sponsors
Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: -Patients aged between 18 to 70 years older of either gender. -Treatment naive patients diagnosed with erosive esophagitis on endoscopy. -All grades of erosive esophagitis, L.A. Classification, grade A to D. -Patients or Legally authorised representative willing to provide written informed consent.
Exclusion criteria
Exclusion criteria: -Patients with Helicobacter pylori infection with RUT Kit -Patients with Barret s esophagus. -Patients with chronic kidney disease. -Pregnant or lactating women. -Signs of gastric malignancy on endoscopy. -Suffering from acute infections. -Obese patients with BMI more than 40kg per metre square
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Healing rate of erosive esophagitisTimepoint: After 8 weeks of treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Symptom controlTimepoint: Baseline, at 4th & 8th Week;Need for rescue medicationTimepoint: At 4th & 8th Week;Compliance/adherence rate assessed via pill count or patient diary and using Brief Medication Questionnaire (BMQ)Timepoint: At 4th & 8th Week;Improvement in quality of life using GERD-HRQL questionnaire.Timepoint: Baseline, at 4th & 8th Week;Dropouts from the studyTimepoint: At 4th & 8th Week;Safety profile and adverse eventsTimepoint: At 4th & 8th Week (or reported by patient during anytime of the study) | — |
Countries
India
Contacts
Public ContactDr Sumit Kumar
Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences
Outcome results
None listed