Health Condition 1: K135- Oral submucous fibrosis
Conditions
Interventions
Intervention1: Intralesional injection of Dexamethasone 4 mg with Hyaluronidase 1500 with Mouth opening device: Administer intralesional injection of Dexamethasone 4mg with Hyaluronidase 1500 IU weekl
Sponsors
Dr Pavithra G
Eligibility
Inclusion criteria
Inclusion criteria: 1. Clinical diagnosis of OSMF 2. Mouth opening between 20 30 mm (according to Lydner s classification group C) 3. No prior treatment for OSMF in the last 6 months
Exclusion criteria
Exclusion criteria: 1. Patients not willing to participate in study 2. OSMF patients with acute dental infection or associated with other lesions like leukoplakia, stomatitis nicotina, carcinoma, etc 3. Patients with reduced mouth opening due to trauma, radiation, surgery, developmental disorders, TMDs or any other disease that mimics OSMF such as systemic sclerosis, tetany (screened by medical history/ questionnaire), etc 4. Patients with early stage of OSMF 5. Patients previously treated with intralesional injection and/or ultrasound therapy for OSMF 6. Patients with any systemic disease such as uncontrolled diabetes, hepatic, respiratory, renal, cardiac, hematological disease, tuberculosis, or immunocompromised states where steroid administration is contraindicated
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Increase in interincisal mouth opening (mm).Timepoint: 3rd week, 6th week | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Reduction in burning sensation (VAS score) 2. Improvement in oral health-related quality of life (OHIP-14 score)Timepoint: 3rd week, 6th week | — |
Countries
India
Contacts
Public ContactDr Zameera Naik
KLE Vishwanath Katti Institute of Dental Sciences
Outcome results
None listed