A study on the comparison between nebulization with ketamine and magnesium sulfate before the surgery in the prevention of after an operation sorethroat in patients going through general anaesthesia(putting the patient to sleep with medicine) with endotracheal intubation(breathing tube in throat)

A study on the comparison between preoperative nebulization with magnesium sulfate and ketamine in the prevention of postoperative sore throat during general anaesthesia with endotracheal intubation in adults - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/09/095191

Enrollment

Registered

2025-09-22

Start date

Unknown

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Magnesium sulfate: Nebulization with magnesium sulfate 500mg (diluted to 5ml with normal saline) will be given once using a wall-attached oxygen drive source 20 minutes before induction

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients who have given written informed consent 2.ASA physical status 1 and 2

Exclusion criteria

Exclusion criteria: 1.Patients with known or anticipated difficult airway 2.Those who had undergone more than 3 attempts at intubation and those requiring airway adjuncts 3.Emergency surgeries 4.BMI more than 35 5.Pregnancy and lactation 6.History of preoperative sore throat or recent upper respiratory tract infection 7.History of oral surgeries, neck surgeries like thyroid surgery

Design outcomes

Primary

Measure	Time frame
To compare the incidence of postoperative sore throat (POST) in adult patients undergoing general anesthesia with endotracheal intubation between patients who received preoperative nebulization with ketamine 50mg and magnesium sulfate 500mgTimepoint: Postoperatively at 0,2,4,6 and 24 hours	—

Secondary

Measure	Time frame
1)To assess the severity of POST (mild, moderate, or severe) in patients who received nebulized ketamine and nebulized magnesium sulfate 2)To evaluate the incidence of other complications in patients who received nebulized ketamine and magnesium sulfate, such as hoarseness of voice and coughTimepoint: Postoperatively at 0,2,4,6 and 24 hours	—

Countries

India

Contacts

Public ContactNivitha G

ESIC medical college and hospital, KK Nagar

drmohankumarrm@gmail.com7259383591

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026