A study to see if adding local amikacin treatment to routine antibiotic injections helps better control surgical wound infections in a rural hospital

To evaluate efficacy of local Amikacin therapy as an adjuvant to parental antibiotic in control of SSI compared to parental antibiotics alone in a rural hospital - nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/09/095157

Enrollment

Registered

2025-09-22

Start date

Unknown

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: nil: nil Intervention2: Parenteral antibiotics with local amikacin injection: Intravenous as in comparator with local instillation of amikacin into wound based on body weight with total

Eligibility

Inclusion criteria

Inclusion criteria: 1) All patients presenting to AVBRH with a case of clean and elective surgeries for abdominal surgeries 2) Patients between 18-74 years of age

Exclusion criteria

Exclusion criteria: 1)Extremes of age less than 18 yrs and greater than 75yrs 2) Patients who are on immune-suppressants, chemo/radiotherapy, steroids other serious pre-existing cardiovascular, pulmonary, and immunological disease. 3) Uncontrolled diabetic patients 4) Local infection

Design outcomes

Primary

Measure	Time frame
Post-surgical infections are becoming a very common entity that can be easily avoided with proper usage of local antibiotic(Amikacin) along with parental antibiotics, we expect that the ASEPSIS scoring system will aid in proving the efficacy of local amikacin on operated site to prevent SSITimepoint: 2 years	—

Secondary

Measure	Time frame
To evaluate efficacy of local Amikacin therapy as an adjuvant to parental antibiotic in control of SSI compared to parental antibiotics alone in a rural hospitalTimepoint: 2 years	—

Countries

India

Contacts

Public ContactAbhiram Chadive

Datta Meghe Institute of Higher Education and Research

abhiramsai99@gmail.com9110397246

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026