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Comparison of Oral Antibiotics Alone versus Oral Plus Intrauterine Antibiotics for Improving Pregnancy Outcomes in Women with Chronic Endometritis after IVF Failure

Role of intrauterine antibiotic infusion combined with oral antibiotic administration in improving pregnancy outcome in women with chronic endometritis diagnosed by CD138 test seeking care for failed IVF. - NIL

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/09/095148
Enrollment
40
Registered
2025-09-19
Start date
Unknown
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N711- Chronic inflammatory disease of uterus

Interventions

Intervention1: Doxycycline: 100 mg BD for 14 Days Intervention2: Metronidazole: 400 mg BD for 14 Days Control Intervention1: Ciprofloxacin: 200 mg/100 ml (3 ml infusion on every 3rd day) for 30 days C

Sponsors

Datta Meghe Institute of Higher Education and Research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Positive diagnosis of Chronic endometriosis Previous IVF Failure Recurrent Pregnancy Loss (RPL) or Recurrent implantation Failure (RIF) No previous live birth FSH and LH levels evaluated on day 2 of menstrual cycle less than 12 IU/ml AMH levels greater than 1.1 ng/ml Progestrone levels evaluated on day 21 of menstrual cycle greater than 2 and less than 25 ng/ml BMI greater than 18.5 and less than 29.9

Exclusion criteria

Exclusion criteria: Diagnosed endometriosis or other related Pelvic Inflammatory Disorder (PID) Current or previous cancer diagnosis. Auto-immune, genetic or reproductive disorders. Reproductive history of pregnancy loss due to genetic abnormalities. Male factor infertility diagnosis.

Design outcomes

Primary

MeasureTime frame
Biochemical Pregnancy Rate (Beta HCG) and Clinical Pregnancy Rate (Gestational Sac and fetal heart sound on USG)Timepoint: 2-3 weeks after embryo transfer and 6-8 weeks post embryo transfer

Secondary

MeasureTime frame
NILTimepoint: NIL

Countries

India

Contacts

Public ContactDr Apoorva Dave

Department of Obstetrics and Gynecology, Datta Meghe Institute of Higher Education and Research

deepti_shrivastav69@yahoo.com9860817801

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026