Health Condition 1: R652- Severe sepsis
Conditions
Interventions
Intervention1: Mitochondrial Supplementation: Thiamin
Vitamin C
Vitamin E
Carnitine
Coenzyme Q
Hydrocortisone
Control Intervention1: NIL: NIL
Sponsors
AIIMS RISHIKESH
Eligibility
Inclusion criteria
Inclusion criteria: Children aged 1 months to 18 years with septic shock, defined as children with suspect or confirmed sepsis and cardiovascular dysfunction as per Phoenix Sepsis Score
Exclusion criteria
Exclusion criteria: Children who require Nil per oral status Children with known HIV/HbSAg/HCV positive status Children with confirmed Immunodeficiency Children with malignancy Children who are known cases of G6PD deficiency/ Oxalate nephropathy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison on median VIS score (Vasoactive inotrope score) during 1st 3 days after initiation of therapy.Timepoint: Comparison on median VIS score (Vasoactive inotrope score) during 1st 3 days after initiation of therapy. | — |
Secondary
| Measure | Time frame |
|---|---|
| Survival status at Day 3, Day 7, and Day 28 following initiation of mitochondrial supplementation in pediatric patients with septic shock. Maximum vasoactive-inotropic score (VIS) on Days 5 and 7 Trend in Pediatric Sequential Organ Failure Assessment (pSOFA) scores from admission through Day 7 or until PICU discharge, whichever occurs earlier. Ventilation-free days and Inotrope-free days within the first 28 days.Timepoint: 3, 7, 28 DAYS | — |
Countries
India
Contacts
Public ContactSrijan Sinha
AIIMS RISHIKESH
Outcome results
None listed