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A study comparing two medicines, Sugammadex and Neostigmine, used to help patients wake up safely after anesthesia

Comparing Sugammadex with Neostigmine for reversal of rocuronium-induced neuromuscular blockade: a randomized controlled study - NIL

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/09/095120
Enrollment
42
Registered
2025-09-19
Start date
Unknown
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Z018- Encounter for other specified special examinations

Interventions

Intervention1: Sugammadex: Dosage: 2 mg/kg IV bolus (adjusted according to actual body weight, given at reappearance of T2 in TOF monitoring) Route: Intravenous (IV) Frequency: Single dose at the en

Sponsors

Indraprastha Apollo Hospital, New Delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA (American Society of Anaesthesiologists), physical status 1 and 3 Age more than 18 years Any surgical procedure under general anesthesia with rocuronium and requiring reversal

Exclusion criteria

Exclusion criteria: Hypersensitivity to any drugs/cyclodextrins Difficult intubation Neuromuscular disorder/neurodegenerative disorders Severe renal and hepatic dysfunction History of Malignant hyperthermia Pregnancy Chronic obstructive airway disease

Design outcomes

Primary

MeasureTime frame
Time required to reach train of four ratio to 0.9 after the administration of sugammadex or neostigmineTimepoint: Every 15 minutes till TOF more than equal to 0.9 and at 2 hours after extubation

Secondary

MeasureTime frame
Postoperative residual paralysis, Adverse effects of neostigmine and sugammadexTimepoint: At 2 hours after extubation

Countries

India

Contacts

Public ContactDharitri Dutta

Indraprastha Apollo Hospital, New Delhi

vikram007mahajan@gmail.com9818518876

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026