Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Amisulpride: Intravenous Amisulpride 10 mg, given as a slow IV injection at induction of anesthesia in patients undergoing elective laparoscopic cholecystectomy.
Control Intervention1:
Sponsors
Dr Saloni Das
Eligibility
Inclusion criteria
Inclusion criteria: Adults of either sex ASA Physical Status I or II scheduled for elective laparoscopic cholecystectomy under general anesthesia
Exclusion criteria
Exclusion criteria: Patients will be excluded if they refuse consent OR belong to ASA physical status class III or IV OR are undergoing emergency laparoscopic surgery OR are smokers or alcoholics OR are pregnant or lactating OR have a history of postoperative nausea/vomiting or motion sickness OR are allergic to amisulpride or palonosetron OR have significant liver or renal disease OR are already on antiemetics, steroids, or psychomimetic drugs preoperatively OR if the surgery duration is greter than or equal to 3 hours
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.To compare the incidence of nausea, vomiting and retching during post-operative 24 hrs in patients undergoing laparoscopic cholecystectomy. 2.To assess the severity of nausea and vomiting as recorded by PONV score. 3.The number and timing of doses of rescue antiemetic used during post op 24 hrs Timepoint: 10 MONTHS | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare: 1. patient satisfaction score and 2. adverse effects related to study drugs. Timepoint: 10 MONTHS | — |
Countries
India
Contacts
Public ContactDr Sulochana Dash
IMS & SUM Hospital
Outcome results
None listed