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Dexmedetomidine or Ketamine: Which Is the Better Add-On for Nerve Blocks in Arm Fracture Surgeries?

Comparison of effect of dexemeditomidine with ketamine as an adjuvant to infraclavicular brachial plexus block in patients undergoing upper limb fracture surgeries: A prospective, randomized non inferiority trial. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/09/095074
Enrollment
140
Registered
2025-09-19
Start date
Unknown
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: inj ketamine: Ketamine as an adjuvant to infraclavicular brachial plexus block in patients undergoing upper limb fracture surgeries Inj Ropivacaine 2mg/kg with inj ketamine 1mg/kg maxim

Sponsors

Department of Anaesthesology and critical care medicine,Indira Gandhi Institute Of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patient posted for elective surgery under infraclavicular block for upper limb fractures. American Society of Anesthesiologists (ASA) physical status I II

Exclusion criteria

Exclusion criteria: 1. Bleeding disorders 2. Patients with damage or disease of the brachial plexus 3. Patients with uncontrolled diabetes mellitus 4. Patients with neuromuscular diseases. 5. Patients with local skin infection at the site of injection or patients with known hypersensitivity to studied drugs. 6. Infection at the injection site 7. Body mass index (BMI) above 40, 8. Drug, alcohol, or substance abuse 9. Pregnancy or breastfeeding, 10. History of heart failure, (HF), heart conduction disorders (except 1st-degree block), and atrial fibrillation (AF) suffering from hepatorenal diseases, and a history of neuropsychological diseases.

Design outcomes

Primary

MeasureTime frame
Comparison of time of first rescue analgesia between the two groups.Timepoint: during first 24 hours postoperatively—

Secondary

MeasureTime frame
1. Duration of sensory blockade 2. Onset of sensory and motor block 3. Postoperative pain score (NRS) at studied timepoints 4. Total analgesic requirements in first 24 hours. 5. Modified Ramsay Sedation score at studied time points. Timepoint: T0 Time to withdrawal of block needle T1 10 mins from T0 T2 15 mins from T0 T3 20 mins from T0 T4 -30 mins from T0 T5 45 mins from T0 T6 60 mins from T0 T7 90 mins from T0 T8- 2 Hours from T0 T9- 4 Hours from T0 T10 6 Hours from T0 T11 - 9 Hours from T0 T12 12 Hours from T0 T13- 18 Hours from T0 T14- 24 Hours from T0—

Countries

India

Contacts

Public ContactDr Arvind kumar

INDIRA GANDHI INSTITUTE OF MEDICAL SCIENCES

arvind007kumar@yahoo.com9534870908

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026