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A study to compare vitamin C with microneedling and platelet-rich fibrin with microneedling for the treatment of interdental papilla (black triangle) defects in the front teeth.

Comparative evaluation of the efficacy of injectable platelet-rich fibrin with microneedling versus vitamin C injection with microneedling in the treatment of Class I interdental papilla defects: A randomized clinical trial. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/09/095031
Enrollment
22
Registered
2025-09-18
Start date
Unknown
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Injectable Platelet-Rich Fibrin with Microneedling: Type: Biological (autologous platelet concentrate) + procedure Route of administration: Intra-papillary injection after microneedlin
repeated at 3-week intervals if required. Duration of intervention: 12 weeks follow-up. Intervention2: Vitamin C Injection with Microneedling: Type: Drug (Vitamin C) + procedure Route of administrat
repeated at 3-week intervals if required. Duration of intervention: 12 weeks follow-up. Control Intervention1: Vitamin C Injection with Microneedling: Type: Drug (Vitamin C) Route of administration

Sponsors

Dr Sai kamali Mandava
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adults aged 18 to 45 years (both genders). Presence of at least one Nordland and Tarnow Class I interdental papilla defect in the maxillary anterior region. Selected teeth free of restorations on cervical or proximal surfaces. Patient reports food lodgment or esthetic concern due to open gingival embrasure. Distance between interproximal contact point and alveolar bone crest less than or equal to 7 mm.

Exclusion criteria

Exclusion criteria: Patients with history of traumatic occlusion. Systemically unhealthy or medically compromised patients. Patients with implants or endodontically treated teeth in the involved area. Pregnant or lactating women. Smokers or alcoholics.

Design outcomes

Primary

MeasureTime frame
Change in papilla defect height mm measured on standardized intraoral photographs.Timepoint: baseline 3 weeks 6 weeks and 12 weeks—

Secondary

MeasureTime frame
Change in papilla width mm papilla deficient area mm papilla deficient volume (mm ), & patient-reported esthetic satisfaction (VAS score).Timepoint: baseline 3 week 6 weeks & 12 weeks;nillTimepoint: nill—

Countries

India

Contacts

Public ContactDr. Amit Walvekar

Coorg Institute of Dental Sciences

dr.kamalibds22@gmail.com08328348424

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026