To know if Platelet rich plasma therapy is effective in intra articular cartilage growth,improve functions and relief pain in patients with moderate osteoarthritis knee.

Effectiveness of autologous platelet rich plasma in grade 2 and grade 3 osteoarthritis knee in terms of controlling pain, improving functions and structural outcome - A prospective interventional study. - Nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/09/095003

Enrollment

Registered

2025-09-17

Start date

Unknown

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M170- Bilateral primary osteoarthritis of knee Health Condition 2: M171- Unilateral primary osteoarthritisof knee

Interventions

Intervention1: AUTOLOGOUS PRP THERAPY IN GRADE 2 AND GRADE 3 OA KNEE: 3 to 5ml PRP (obtained from 30ml of blood through centrifuge) is given in to the affected knee joint(grade 2 and grade 3 OA knee),

Eligibility

Inclusion criteria

Inclusion criteria: Patients who are willing for follow up, confirmed cases of osteoarthritis knee, kellgren Lawrence radiological grade 2 and grade 3 osteoarthritis knee

Exclusion criteria

Exclusion criteria: Patients with grade 1 and grade 4 osteoarthritis knee,patients with heart diseases using antiplatelets and anti-coagulation medications , secondary osteoarthritis knee, sepsis , platelets disorders or diseases , any intervention in last 3 months , any immunodeficiency, autoimmune, collagen vascular diseases , any contraindications for MRI , any contraindications to platelets rich plasma therapy.

Design outcomes

Primary

Measure	Time frame
Improvement in terms of pain control, functional improvement, and cartilage growth.Timepoint: after baseline evaluation patients are given PRP injections into the affected knee joint every week for 4 weeks,then they are followed up every month for 3 months. At follow up patients are asked about subjective improvement and assessed for functional improvement and at the end of 3 months post last dose of PRP INJECTION structural outcome is evaluated with the help of MRI.	—

Measure

Time frame

Improvement in terms of pain control, functional improvement, and cartilage growth.Timepoint: after baseline evaluation patients are given PRP injections into the affected knee joint every week for 4 weeks,then they are followed up every month for 3 months. At follow up patients are asked about subjective improvement and assessed for functional improvement and at the end of 3 months post last dose of PRP INJECTION structural outcome is evaluated with the help of MRI.

—

Secondary

Measure	Time frame
NilTimepoint: Nil	—

Countries

India

Contacts

Public ContactDr Gudise Sambi Reddy

Esic medical College and hospital

sambireddy57@yahoo.com9848260927

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026