A study comparing Preoperative Nebulization with Magnesium Sulphate versus Lignocaine to Prevent Post Extubation Sore Throat in Patients undergoing Laparoscopic Surgeries at SMS Medical College, Jaipur.

A Randomized comparative Study To Assess Post Extubation Sore Throat using Preoperative Nebulization with Magnesium Sulphate versus Lignocaine in Patients undergoing Laparoscopic Surgeries at SMS Medical College, Jaipur. - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/09/094955

Enrollment

150

Registered

2025-09-17

Start date

Unknown

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K800- Calculus of gallbladder with acutecholecystitis Health Condition 2: K402- Bilateral inguinal hernia, withoutobstruction or gangrene Health Condition 3: K819- Cholecystitis, unspecified Health Condition 4: K358- Other and unspecified acute appendicitis Health Condition 5: K429- Umbilical hernia without obstruction or gangrene Health Condition 6: N950- Postmenopausal bleeding

Interventions

Intervention1: Lignocaine Group: Nebulization of patients 30 minutes prior to surgery using 4 ml of 2 percentage Lignocaine over 15 minutes. Control Intervention1: Magnesium Sulphate: Nebulization of

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients undergoing elective laparoscopic surgeries under General Anaesthesia. 2.Patients giving written informed consent 3.Patients having American Society of Anesthesiologist (ASA) physical status 1 and 2. 4.Patients of age more than 18 years. 5.Patients with Mallampati grade 1 or 2.

Exclusion criteria

Exclusion criteria: 1.Patient who is part of any other study. 2.Patients with upper respiratory tract infection. 3.Patients with nasogastric tube and any nasal or throat pack require intraoperatively. 4.Allergy to study drugs.

Design outcomes

Primary

Measure	Time frame
1.To assess and compare the proportion of sore throat ( swallowing and rest) between two groups after extubation till 48 hours.Timepoint: 1.Postoperative sore throat will be checked ( swallowing and rest) between two groups at 2 hours,8hours,24hours and 48hours after extubation.	—

Secondary

Measure	Time frame
1.To assess & compare the proportion of hoarseness of voice & cough between two groups after extubation till 48 hours. 2.To assess & compare haemodynamic parameters-Heart rate,Systolic blood pressure,Diastolic blood pressure,Mean arterial pressure from induction to extubation at every 10 minutes interval. 3.To assess & compare side effects nausea, vomiting, hypotension & respiratory depression in both groups. Timepoint: 1.Hoarseness of voice & Cough will be checked between two groups at 2hours,8hours,24hours & 48hours after extubation 2.Haemodynamic parameters-Heart rate,Systolic blood pressure,Diastolic blood pressure,Mean arterial pressure will be checked from induction to extubation at every 10 minutes interval. 3.Side effects nausea, vomiting, hypotension & respiratory depression will be checked in both groups intraoperatively & postoperatively.	—

Measure

Time frame

1.To assess & compare the proportion of hoarseness of voice & cough between two groups after extubation till 48 hours. 2.To assess & compare haemodynamic parameters-Heart rate,Systolic blood pressure,Diastolic blood pressure,Mean arterial pressure from induction to extubation at every 10 minutes interval. 3.To assess & compare side effects nausea, vomiting, hypotension & respiratory depression in both groups. Timepoint: 1.Hoarseness of voice & Cough will be checked between two groups at 2hours,8hours,24hours & 48hours after extubation 2.Haemodynamic parameters-Heart rate,Systolic blood pressure,Diastolic blood pressure,Mean arterial pressure will be checked from induction to extubation at every 10 minutes interval. 3.Side effects nausea, vomiting, hypotension & respiratory depression will be checked in both groups intraoperatively & postoperatively.

—

Countries

India

Contacts

Public ContactDr Arunkumar

SMS Medical College

rupihar@gmail.com9899785993

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026