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Comparison between intravenous Dexamethasone and intravenous Ondansetron for prevention of low blood pressure after spinal anesthesia in caesarean delivery among pregnant women

Comparison between intravenous Dexamethasone and intravenous Ondansetron for prevention of post spinal hypotension in patients undergoing elective lower segment caesarean section : A randomized controlled trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/09/094940
Enrollment
285
Registered
2025-09-16
Start date
Unknown
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O00-O9A- Pregnancy, childbirth and the puerperium

Interventions

Intervention1: Intravenous Dexamethasone and intravenous Ondansetron 30 minutes prior to spinal anaesthesia: On the morning of surgery Inj Dexamethasone 8 mg diluted in 0.9% normal saline (total volum

Sponsors

AIIMS New Delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Pregnant women undergoing elective LSCS under Spinal anaesthesia 3. Singleton pregnancy 4. American society of anaesthesiologists physical status( ASA) 2 5. Gestational age more than 37 weeks

Exclusion criteria

Exclusion criteria: 1. Gestational diabetes mellitus 2. Chronic diabetes mellitus 3. Hypertensive disorders of pregnancy 4. Cardiovascular insufficiency 5. BMI more than 40 kg/m2 6. Allergy to Dexamethasone or Ondansetron 7. Long QTsyndrome 8. Patients on long term steroid treatment 9. Any contraindication to spinal anaesthesia 10. Patient refusal

Design outcomes

Primary

MeasureTime frame
To compare the incidence of post spinal hypotension between the study groupsTimepoint: Systolic blood pressure will be recorded every 1 minutes till delivery—

Secondary

MeasureTime frame
1. To compare the number of boluses of PhenylephrineTimepoint: ;2. To compare incidence of post delivery hypotensionTimepoint: Systolic blood pressure will be measured every 5 minutes after delivery till the end of the surgery;3. To compare the incidence of maternal bradycardia, nausea/vomiting, shiveringTimepoint: ;4. To compare the neonatal outcome (APGAR Score, umbilical artery Ph, blood sugarTimepoint: ;5. Quality of recovery (QoR 15)Timepoint: on the morning of surgery and 24 hours after surgery—

Countries

India

Contacts

Public ContactIndrani Das

AIIMS New Delhi

drshail.kumar@gmail.com8745027472

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026