Health Condition 1: F330- Major depressive disorder, recurrent, mild Health Condition 2: F331- Major depressive disorder, recurrent, moderate Health Condition 3: F320- Major depressive disorder, singleepisode, mild Health Condition 4: F321- Major depressive disorder, singleepisode, moderate
Conditions
Interventions
Intervention1: Yoga: A specific yoga module of 1 hour duration, 6 days a week is delivered for patients with depression for a duration of 4 to 12 weeks (depending on the randomised arm)
Control Interv
Sponsors
Indian Council for Medical Research
Collaborative Research Centre for MindBody Interventions through Yoga CCRYN NIMHANS collaboration
Eligibility
Inclusion criteria
Inclusion criteria: 1)Patients with mild to moderate Depressive disorder (MDD or RDD)(HRDS score between 7 and 24) Without psychotic symptoms and without suicidality 2)Drug na ve for current episode or drug free for 4 weeks in the current episode 3)Comorbid anxiety disorder(s) are allowable if they do not interfere with participation 4)Written informed consent
Exclusion criteria
Exclusion criteria: 1)Suicidal ideation with intent in the prior year (according to Columbia Suicide Severity Rating Scale) 2)Patients who have received structured specific yoga practices in the past 1 month 3)Already on ayurveda or Unani or homeopathy medications 4)Patients who had received ECT in past 3 months 5)History of bipolar disorder, schizophrenia, schizoaffective disorder, substance abuse or dependence (except tobacco), OCD 6)Any severe medical comorbidities 7)Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is feasibility of the SMART design implementation across key domains.Timepoint: Baseline, 4 weeks, 8 weeks, 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Trends in depressive symptom changes per treatment sequence, examining effect sizes and patternsTimepoint: Baseline, 4 weeks, 8 weeks, 12 weeks;Preliminary trends in biomarker measure changes (neurocognitive, HRV, GABA MRS, fMRI connectomes) related to treatment sequences and response.Timepoint: Baseline, 4 weeks, 8 weeks, 12 weeks | — |
Countries
India
Contacts
Public ContactDr Daiveek PG
National Institute of Mental Health And Neurosciences (NIMHANS), Bengaluru
Outcome results
None listed