Comparative Study Between Two Types of Courses of Thoracic Radiotherapy in Stage IV Lung Cancer

A Comparative Study Between Two Thoracic Radiotherapy Schedules for Palliation of Symptoms, Radiological Responses and Acute Toxicities in Stage IV Non-Small Cell Lung Cancer - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/09/094928

Enrollment

Registered

2025-09-16

Start date

Unknown

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C34- Malignant neoplasm of bronchus andlung

Interventions

Intervention1: 20 Gy in 5 consecutive days: Comparison between two palliative thoracic radiotherapy regimens in stage IV Non Small Cell Lung Cancer. Control Intervention1: 17 Gy in 2 fractions, one we

Eligibility

Inclusion criteria

Inclusion criteria: 1. Histologically or Cytologically proven Non-Small Cell Lung Cancer 2. Stage IV Lung Cancer, according to AJCC Staging 9th version 3. Age more than 18 years and less than 70 years 4. Any Sex 5. ECOG Grade 0-3 6. Patients willing to take part in the study with an informed written consent.

Exclusion criteria

Exclusion criteria: 1. Small Cell Lung Cancer 2. Patients with collagen vascular disease or any other systemic comorbidities or severe uncontrolled infection, which may alter treatment outcome. 3. Pregnant or Nursing Women 4. Patients who had deranged blood parameters, impaired liver function, renal function and bone marrow suppression. 5. Patients refusing to take part in the study.

Design outcomes

Primary

Measure	Time frame
To compare between two radiotherapy regimens p 20 Gy/5# in 5 consecutive days and 17 Gy/2# over a week apart and fine the more effective one in terms of: 1.Symptom relief 2.To check acute toxicities using RTOG scale, and manage patients, if necessary 3.To evaluate the variation in symptomatic relief associated with different presenting symptoms when administering two distinct radiotherapy regimens, using LCSS scale/RTOG 4 point scaleTimepoint: 18 months	—

Measure

Time frame

To compare between two radiotherapy regimens p 20 Gy/5# in 5 consecutive days and 17 Gy/2# over a week apart and fine the more effective one in terms of: 1.Symptom relief 2.To check acute toxicities using RTOG scale, and manage patients, if necessary 3.To evaluate the variation in symptomatic relief associated with different presenting symptoms when administering two distinct radiotherapy regimens, using LCSS scale/RTOG 4 point scaleTimepoint: 18 months

—

Secondary

Measure	Time frame
NILTimepoint: 18 months	—

Countries

India

Contacts

Public ContactDr Suranjan Maitra

IPGMER and SSKM Hospital, Kolkata

suranjanmaitra9@gmail.com9933099901

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026