Comparing Local Spray( Vitamin C and Glutathione) Application and Laser for the treatment of Dark gums: A Randomized Clinical Trial

Comparative Analysis of Topical Glutathione and Ascorbic Acid vs. Laser Therapy for Gingival Depigmentation: A Randomized Clinical Trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/09/094917

Enrollment

Registered

2025-09-16

Start date

Unknown

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Glutathione and Ascorbic acid spray: A topical spray containing glutathione and ascorbic acid (ETHIGLO Spray, ETHICARE REMEDIES, Glutathione 50mg/ml, Vitamin C 20mg/ml). Control Interve

Eligibility

Inclusion criteria

Inclusion criteria: Systemically healthy individuals Participants above 18 years Participants with physiologic melanin pigmentation Healthy gingival tissues without active Periodontal disease Participants with aesthetic concern

Exclusion criteria

Exclusion criteria: Pathological pigmentation of gingiva Clinically evident gingivitis Known allergic to glutathione and vitamin C Using tobacco in any form History of depigmentation procedures Pregnant and lactating women Systemic conditions and drugs affecting pigmentation

Design outcomes

Primary

Measure	Time frame
Dummett oral pigmentation index(DOPI) Gingival pigmentation index(GPI)Timepoint: 4, 12 and 24 months	—

Secondary

Measure	Time frame
Patient satisfaction and acceptance questionnaire RecurrenceTimepoint: 4,12 and 24 weeks	—

Countries

India

Contacts

Public ContactDr Sreenivas Nagarakanti

Narayana dental college and hospital

sreenivasnagarakanti@gmail.com9985664566

Outcome results