Effect of small bone perforations with and without low-level laser treatment on speeding up tooth movement during straightening of crowded lower front teeth: A randomized controlled trial

Effect of micro-osteoperforations with and without low-level laser therapy on accelerating tooth movement during alignment in mandibular anterior crowding: A randomized controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/09/094909

Enrollment

Registered

2025-09-16

Start date

Unknown

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K088- Other specified disorders of teethand supporting structures

Interventions

Intervention1: Micro-osteoperforation followed by Low Level Laser Therapy: Low-level laser therapy, also known as photobiomodulation, is a non-invasive technique that uses low-intensity laser light to

Eligibility

Inclusion criteria

Inclusion criteria: Participants aged between 18 to 35 years. Extraction case with moderate crowding of mandibular anterior region, (Quantified as 4 to 6 mm of crowding according to Little s Irregularity Index) Participants with fully erupted mandibular anterior teeth (canine to canine) Participants willing to participate in the study with informed consent provided.

Exclusion criteria

Exclusion criteria: Severe crowding or malocclusion. Participants with prior orthodontic treatment Participants with history of orthodontic surgery Participants with significant periodontal disease (confirmed by clinical examination and radiographs). Participants who are pregnant or lactating. Participants with systemic conditions that could interfere with orthodontic treatment (such as uncontrolled diabetes, uncontrolled hypertension, any infections, etc.) Current smokers or individuals who have smoked within the last 6 months. Participants who are under medications affecting bone metabolism or healing (e.g., corticosteroids, bisphosphonates, etc.)

Design outcomes

Primary

Measure	Time frame
There is some difference in the rate of orthodontic alignment in mandibular anterior teeth between the patients receiving mini-screw-assisted micro-osteoperforations combined with low-level laser therapy and the patients receiving micro-osteoperforations alone.Timepoint: Baseline, 28th Day, 56th Day, 84th Day	—

Secondary

Measure	Time frame
There is no significant difference in the rate of orthodontic alignment in mandibular anterior teeth between the patients receiving mini-screw-assisted micro-osteoperforations combined with low-level laser therapy and the patients receiving micro-osteoperforations (MOPs) alone.Timepoint: Baseline, 28th Day, 56th Day, 84th Day	—

Countries

India

Contacts

Public ContactDr Hrithik R Patkar

Maharashtra Institute of Dental Sciences and Research Dental College, Latur

drpravinkumar08@gmail.com9404366634

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026