Magnesium sulphate and its help in reducing the postoperative pain and ileus

A RANDOMISED CONTROLLED TRIAL TO STUDY THE EFFECT OF PREOPERATIVE SYSTEMIC MAGNESIUMSULFATE INFUSION ON POST OPERATIVE PAIN AND POST OPERATIVE ILEUS FOLLOWING NON LAPAROSCOPIC MAJOR ABDOMINAL SURGERIES - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/09/094904

Enrollment

100

Registered

2025-09-16

Start date

Unknown

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 4- Measurement and Monitoring

Interventions

Intervention1: MagnesiumSulphate: 40mg/kg magnesium sulfate in 100ml ns 30 minutes before induction as IV infusion Control Intervention1: normal saline: normal saline infusion given preoperatively

Eligibility

Inclusion criteria

Inclusion criteria: Patients of age more than 18 and less than 60 years. Patients undergoing open abdominal surgeries. Patients who received ASA 1, 2 in Pre anaesthetic check. Patients with normal Serum Magnesium levels. Patients who consented to be included in the study

Exclusion criteria

Exclusion criteria: Patients of age less than 18 and more than 60 years. Patients with Liver failure, Renal failure, Heart block, Arrythmia, EF less than 45 percent, Pregnancy, Neurological disorders, Hypersensitivity Patients with serum magnesium above normal. Patients with Blood glucose more than 200mg/dl on the day of surgery. Patient on Calcium channel blockers. Patients undergoing laparoscopic abdominal surgeries Those who don not give consent to be included in the study.

Design outcomes

Primary

Measure	Time frame
to assess the reduction of duration of post operative ileus on Mgso4 infusionTimepoint: 1, 2, 4, 12, 24 hrs post operatively	—

Secondary

Measure	Time frame
to assess the reduction of post operative pain on Mgso4 infusionTimepoint: 1, 2, 4, 12, 24 hours post operatively	—

Countries

India

Contacts

Public ContactDr K Muthu Raj

Chettinad hospital and research institute

drmuthurajkasinathan@gmail.com7305705536

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026