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A study comparing the effects of ketamine and dexmedetomidine with paracetamol on pain relief after laparoscopic gynecological cancer surgery.

Comparative study between preemptive Ketamine and Dexmedetomidine with intravenous Paracetamol for post-operative analgesia in laparoscopic gynecological cancer surgeries: A Double-blinded randomized controlled trial. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/09/094890
Enrollment
140
Registered
2025-09-16
Start date
Unknown
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C55- Malignant neoplasm of uterus, partunspecified

Interventions

Intervention1: Ketamine with IV Paracetamol: Ketamine at a dose of 0.5 mg/kg, diluted in 10 mL of NS and administered Intravenously over 10 minutes and intravenous Paracetamol 1gm(100ml) is infused, 2

Sponsors

Shubham Kumar
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Female age 18-80 years. Patients of ASA physical status 1,2 & 3. Female Undergoing elective laparoscopic gynecological cancer surgeries.

Exclusion criteria

Exclusion criteria: Patient s refusal to participate. Patients of psychiatric disorders and unable to understand VAS and substance abuse. Drug allergy. Pregnant females. History of any underlying cardiac, hepatic, renal dysfunction.

Design outcomes

Primary

MeasureTime frame
To compare the efficacy and safety of pre-emptive ketamine with Intravenous Paracetamol vs pre-emptive dexmedetomidine with Intravenous paracetamol for postoperative analgesia in patients undergoing laparoscopic gynaecological cancer surgeries.Timepoint: Immediately after extubating, 0hr, 15min, 30min, 45min, 60min, 2hour, 4hour, 8hour,12 hour, 24hour—

Secondary

MeasureTime frame
1. To compare the hemodynamic stability between two groups. 2. To compare time to first rescue analgesic need & total opioids consumption in 24hour after surgery. 3. To observe the incidence of side effects & complication.Timepoint: Immediately after extubating, 0hr, 15min, 30min, 45min, 60min, 2hour, 4hour, 8hour,12 hour, 24hour—

Countries

India

Contacts

Public ContactShubham Kumar

Indira Gandhi Institute of Medical Sciences, Patna

drpujachoudhary16@gmail.com8758272237

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026