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Do vitamin B12 tablets work as well as vitamin B12 injections for pregnant women with mild to moderate vitamin B12 deficiency?

Comparison of effect of oral versus intramuscular vitamin b12 administration on its serum levels 3 months post treatment among pregnant women with mild and moderate vitamin b12 deficiency in second trimester - a Randomized controlled trial - B12

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/09/094880
Enrollment
130
Registered
2025-09-16
Start date
Unknown
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E538- Deficiency of other specified B group vitamins

Interventions

Intervention1: T. Vitamin b12 (cyanocobalamin): 1000mcg PO daily for 90 days Control Intervention1: Inj Vitamin B12: 1000mcg IM daily for 7 days - weekly for 6 weeks - monthly for 3months total

Sponsors

Intramural research fund committee JIPMER
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Pregnant women 18 years and above between 14-28 weeks diagnosed with Vitamin B12 deficiency (Serum Vitamin B12 levels less than 200pg/ml)

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
To compare the effect of oral versus intramuscular vitamin b12 administration on its mean serum levels 3 months post treatment among pregnant women with mild to moderate Vitamin B12 deficiency in second trimester of pregnancyTimepoint: Comparison of serum Vitamin B12 between the two groups of intervention at 3 months post treatment—

Secondary

MeasureTime frame
To compare the changes in hematological parameters(hemoglobin, MCV, MCH, MCHC, peripheral smear, platelet count, total leukocyte counts) 3 months post treatment between the groups To compare the adverse effects between the two groupsTimepoint: Comparison of hematological parameters between the two groups of intervention at basline, 1 month, 2 month & 3 month post initiation of treatment—

Countries

India

Contacts

Public ContactDr. Ashwini Vishalakshi.L

Jawaharlal Institute of Postgraduate Medical Education and Research

akshivishal@gmail.com9600203086

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026