Health Condition 1: K802- Calculus of gallbladder without cholecystitis
Conditions
Interventions
Intervention1: Intravenous Amisulpride with intravenous Ondansetron: Intravenous Amisulpride 5mg bolus with intravenous Ondansetron 4mg bolus will be given in first 30min of surgery total lasting for
Sponsors
Dr Ashutosh Singh
Eligibility
Inclusion criteria
Inclusion criteria: 1) Scheduled to undergo elective laparoscopic cholecystectomy under general anaesthesia lasting for atleast 1 hour under GA with inhalational agent. 2) Ability to provide informed consent for participation in the study.
Exclusion criteria
Exclusion criteria: 1) Patients with a history of severe adverse reactions to any of the study medications. 2) Known hypersensitivity to any of the study drugs. 3) History of significant cardiac, renal, hepatic, or neurological disorders. 4) Pregnancy or breastfeeding. 5) Use of antiemetic medications within 24 hours prior to surgery. 6) Chronic opioid use or history of substance abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) To evaluate the incidence of emetic episodes within 24 hours post-surgery in both treatment groups. 2) To assess the severity of nausea at 1, 2, 6 and 24 hours post-surgery in both treatment groups using a patient verbal rating scale. 3) To predict the incidence of PONV using the Apfel scoring system in both treatment groups. Timepoint: To assess at 1st, 2nd, 6th and 24th hour post-surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| To determine the need for rescue medication for PONV in each treatment groups Timepoint: Within 24hours | — |
Countries
India
Contacts
Public ContactDr Ashutosh Singh
Shri Guru Ram Rai Institute of Medical and Health Sciences , Dehradun
Outcome results
None listed