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Comparison of Nebulized and Intranasal Dexmedetomidine with Saline to Reduce Stress Response During Intubation in Adults Undergoing Surgery

Evaluation of Nebulized Dexmedetomidine, Intranasal Dexmedetomidine and Nebulized Saline given pre-operatively to blunt intubation response during adult endotracheal intubation A Randomized control trial. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/09/094846
Enrollment
100
Registered
2025-09-16
Start date
Unknown
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I00-I99- Diseases of the circulatory system Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Dexmedetomidine nebulization: Nebulize 1 g/kg dexmedetomidine added to 4ml saline for nebulization in the preoperative holding area. Control Intervention1: Dexmedetomidine intranasal s

Sponsors

Academic Investigator Initiated Project
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adult patients aged 18-65, falling under ASA category 1 and 2 who will be undergoing elective surgery requiring endotracheal intubation as part of general anaesthesia will form the study population.

Exclusion criteria

Exclusion criteria: Known allergy to dexmedetomidine Hypertensive patients on betablockers Severe cardiovascular, hepatic, or renal disease Pregnancy or lactation History of difficult intubation

Design outcomes

Primary

MeasureTime frame
To compare the haemodynamic parameters, post induction in patients receiving either nebulized dexmedetomidine, intranasal dexmedetomidine or nebulized saline.Timepoint: At the end of study duration data will be collected study duration 12 months—

Secondary

MeasureTime frame
To assess the change in requirement of propofol for induction in patients receiving dexmedetomidine.Timepoint: At the end of study duration data will be collected study duration 12 months—

Countries

India

Contacts

Public ContactDr Anitha Prashanth

Fortis Hospitals Limited

anithaprashanth16@gmail.com9900107837

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026