None listed
Conditions
Interventions
Intervention1: Intravenous dexmedetomidine(0.5 microgram/kg): 54 Patients receiving 0.5 microgram dose of intravenous dexmedetomidine diluted into 100ml normal saline given iv just prior to subarachno
Sponsors
SRMSIMS
Eligibility
Inclusion criteria
Inclusion criteria: Patients aged 18-60 years of either sex with ASA physical status 1 and 2
Exclusion criteria
Exclusion criteria: ASA Grade 3 and 4 2) Unwillingness to be a part of the trial or patient refusal 3) Allergytothestudydrugs 4) Age less than 18 years and more than 60 years 5) History of major trauma to spine or History of nuerodegenerative diaorders 6) Uncontrolled Diabetes mellitus/ Hypertension 7 Systemicillnessesinvolvingcardiovascular,nervousorrespiratorysystem,anyrenalorliverd isease 8) Hemodynamically unstable patient 9) Pregnancy 10)Patients with known spinal deformities
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. To evaluate the effect of different doses of dexmedetomidine and clonidine as adjunct agent on hemodynamics in patients undergoing elective surgical procedures under regionalanaesthesia. 2. To evaluate the effect of three different doses of ketamine-propofol combination as inductionagentonrecoveryprofileofpatientsundergoingelectivesurgicalprocedures under generalanaesthesia.Timepoint: Haemodynamic variables such as heart rate (HR), systolic blood pressure (SBP), diastolic bloodpressure (DBP) and mean arterial blood pressure (MABP) will be monitored at baseline (Prior to intravenous injection), immediately post injection and upto 120 minutes(3,6,10,15,30,45,60,75,90,105,120minutes) | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the evaluation of different doses of dexmedtomidine & Clonidine as an adjuvant on hemodynamic & recovery profile in patients undergoing elective surgicalprocedures under regional anaesthesia. To check sideeffects of both the drugs in patients undergoing elective surgical procedures under regional anaesthesiaTimepoint: PONV,vomiting,headache & tachycardia to be assesed after immediate end of surgery to hourly upto 6 hours(1,2,3,4,5,6hours respectively) | — |
Countries
India
Contacts
Public ContactDr. Akhilesh Pahade
Department of Anaesthesia Shri Ram Murthy Smarak Institute of Medical Sciences (SRMSIMS) .
Outcome results
None listed