Health Condition 1: A419- Sepsis, unspecified organism
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Nil: Nil
Intervention3: Nil: Nil
Sponsors
Manipal Academy of Higher Education, Manipal
Eligibility
Inclusion criteria
Inclusion criteria: Patient Group 1. Adult patients (age 18 and above) admitted to the ICUs with sepsis, shock and other inflammatory conditions like trauma, poisoning, pancreatitis. 2. SOFA score greater than 2 Healthy Controls 1. Healthy adults (18 years and above) not admitted to the hospital or those with well-controlled underlying conditions (hypertension, diabetes etc.) 2. Able and willing to provide the informed consent.
Exclusion criteria
Exclusion criteria: Patient group 1. Age less than 18 years 2. Pregnant or breast-feeding women 3. Confirmed viral, fungal, parasitic, polymicrobial infections. 4. Patients with a withdrawal of care decision at time of inclusion 5. Patients whose anticipated duration of hospitalisation in ICU is estimated less than 48 hours. 6. Patient with restricted liberty or under legal protection 7. Expected lifespan less than 3 months due to pre-existing co-morbidities 8. Blood transfusion greater than 4 units in past week 9. Second admission to ICU or previous enrolment in study (within same hospital admission) Transfer from other hospital ICU Healthy Controls 1. Age less than 18 years 2. Pregnant or breast-feeding 2. Infected with any infectious diseases 3. Hemophilia, severe coagulation disorders or impaired venous access 4. Prolonged antibiotic usage in the last 3 months 5. History of sepsis/septic shock in the last 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Association of plasma and immune cell mediators with 28 day mortalityTimepoint: Three time points from ICU admission to 28 day follow up | — |
Secondary
| Measure | Time frame |
|---|---|
| NILTimepoint: NIL | — |
Countries
India
Contacts
Public ContactAnusree A
Kasturba Medical College, Manipal
Outcome results
None listed