To compare complete and incomplete removal of infectious tissue in Large cyst-like lesions involving root tips during Endodontic Microsurgery in anterior teeth.

Surgical Outcome of Selective or Complete Curettage Performed in Large Cyst-like Periapical Lesions of Endodontic Origin: A Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/09/094656

Enrollment

Registered

2025-09-12

Start date

Unknown

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis Health Condition 2: K041- Necrosis of pulp Health Condition 3: K045- Chronic apical periodontitis Health Condition 4: K048- Radicular cyst Health Condition 5: K046- Periapical abscess with sinus Health Condition 6: K047- Periapical abscess without sinus

Interventions

Intervention1: Selective curettage: Two visit Nonsurgical Root Canal Therapy will be performed. Periapical surgery will be performed after 7 days in which selective curettage of the lesion will be per

Eligibility

Inclusion criteria

Inclusion criteria: Asian healthy (ASA I) subjects of either gender between 18 and 60 years of age. Radiographically diagnosed with a large cyst-like periapical lesion larger than 10mm associated with non-vital permanent anterior teeth. Acceptable periodontal status (probing depth less than 4mm)

Exclusion criteria

Exclusion criteria: a) Patients with inadequate oral hygiene or periodontal health. b)Patients with systemic conditions that could compromise the healing. c)Pregnant or lactating women. d)History of previous periapical surgery on the same tooth. e)Patients not willing to participate in the study.

Design outcomes

Primary

Measure	Time frame
1. To evaluate the surgical outcome of selective curettage performed in large- cyst like periapical lesions of endodontic origin in permanent anterior teeth. 2. To evaluate the surgical outcome of complete curettage performed in large- cyst like periapical lesions of endodontic origin in permanent anterior teeth. 3. To compare the above. Timepoint: 6 months and 1 year	—

Secondary

Measure	Time frame
1. To evaluate the postoperative pain, swelling, analgesics needed, and patient-reported quality of life (OHRQoL) for selective curettage performed in large-cyst like periapical lesions of endodontic origin in permanent anterior teeth. 2. To evaluate the postoperative pain, swelling, analgesics needed, and patient-reported quality of life (OHRQoL) for complete curettage performed in large-cyst like periapical lesions of endodontic origin in permanent anterior teeth. 3. To compare the above.Timepoint: 1 week	—

Measure

Time frame

1. To evaluate the postoperative pain, swelling, analgesics needed, and patient-reported quality of life (OHRQoL) for selective curettage performed in large-cyst like periapical lesions of endodontic origin in permanent anterior teeth. 2. To evaluate the postoperative pain, swelling, analgesics needed, and patient-reported quality of life (OHRQoL) for complete curettage performed in large-cyst like periapical lesions of endodontic origin in permanent anterior teeth. 3. To compare the above.Timepoint: 1 week

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Countries

India

Contacts

Public ContactDr Sidhartha Sharma

Center for Dental Education and Research, All India Institute of Medical Sciences, New Delhi-110029

sid.aiims@gmail.com958254655

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026