Study in patients needing root canal treatment to compare calcium hydroxide and triple antibiotic paste, with or without silver nanoparticles, for infection control and pain relief.

A comparative evaluation of calcium hydroxide and triple antibiotic paste with and without silver nanoparticles on microbial load and post operative pain: An in vivo study. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/09/094546

Enrollment

Registered

2025-09-10

Start date

Unknown

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K041- Necrosis of pulp

Interventions

Intervention1: Calcium hydroxide without silver nanoparticles.: Intracanal medicament consisting of calcium hydroxide without silver nanoparticles placed inside the root canal for 7 days after the b

Eligibility

Inclusion criteria

Inclusion criteria: 1. Subjects which have non-contributory medical history. 2. Teeth with pulpal necrosis and periapical pathosis will be selected, PAI score more than 2 less than 5. 3. Teeth with enough crown structure for adequate isolation with rubber dam. 4. Teeth with favourable root morphology 5. Teeth that are restorable. 6. Teeth with completely formed apices and without internal resorption will be selected.

Exclusion criteria

Exclusion criteria: 1. Medically compromised patients or patients who are allergic to drugs. 2. PAI score equal to or more than 5. 3. Pregnant females 4. Patients with Immunocompromising disorders. 5. Teeth with abscess, fistula or sinus tract, previously root canal treated teeth. 6. Grade I mobility or pocket depth more than 5 mm or radiographic evidence of external or internal root resorption. 7. Teeth that are unrestorable. 8. Antibiotics use within the past 30 days and patients who have some general disease. 9. Teeth with incompletely formed apices and internal resorption.

Design outcomes

Primary

Measure	Time frame
Microbial load reduction and impact on post operative pain.Timepoint: 1 year 6 months	—

Secondary

Measure	Time frame
Antimicrobial efficacy of calcium hydroxide, as an intracanal medicament with and without silver nanoparticles.Timepoint: 1 year 6 months;Antimicrobial efficacy of triple antibiotic paste, as an intracanal medicament with and without silver nanoparticles.Timepoint: 1 year 6 months;Post-operative pain following the use of calcium hydroxide as an intracanal medicament, with and without the addition of silver nanoparticles.Timepoint: 1 year 6 months;Post-operative pain following the use of triple antibiotic paste as an intracanal medicament, with and without the addition of silver nanoparticles.Timepoint: 1 year 6 months	—

Measure

Time frame

Antimicrobial efficacy of calcium hydroxide, as an intracanal medicament with and without silver nanoparticles.Timepoint: 1 year 6 months;Antimicrobial efficacy of triple antibiotic paste, as an intracanal medicament with and without silver nanoparticles.Timepoint: 1 year 6 months;Post-operative pain following the use of calcium hydroxide as an intracanal medicament, with and without the addition of silver nanoparticles.Timepoint: 1 year 6 months;Post-operative pain following the use of triple antibiotic paste as an intracanal medicament, with and without the addition of silver nanoparticles.Timepoint: 1 year 6 months

—

Countries

India

Contacts

Public ContactDr Tarun Kumar

Dasmesh Institute of Research and Dental Sciences, Faridkot

drtarunkumar@hotmail.com9888666699

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026