A Comparison of Inspiratory-to-Expiratory Ratios in Patients on Ventilators During Laparoscopic Surgery

Comparison of Three Inspiratory-to-Expiratory Ratio During Mechanical Ventilation in Patients Undergoing Laparoscopic Surgeries: A Randomized Clinical Trial - nil

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/09/094483

Enrollment

Registered

2025-09-09

Start date

Unknown

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Group B: Patient to be ventilated with Inspiratory to Expiratory ratio of 1:2 Control Intervention1: Group A: Patient to be ventilated with Inspiratory to Expiratory ratio of 1:1.5 Cont

Eligibility

Inclusion criteria

Inclusion criteria: 1) ASA physical status I and II 2) Patients scheduled for elective laparoscopic surgeries 3) BMI 18.5 to 30 kg per metre square

Exclusion criteria

Exclusion criteria: 1) Patient refusal 2) History of COPD, asthma, or restrictive lung disease 3) History of significant cardiovascular disease 4) Severe hepatic or renal impairment 5) Pregnancy 6) Emergency surgeries ? BMI greater than 30 kg per metre square

Design outcomes

Primary

Measure	Time frame
To compare the effects of volume-controlled ventilation with I:E ratios of 1:1.5, 1:2, and 1:2.5 on respiratory mechanics in patients undergoing laparoscopic surgeries.Timepoint: 0 min, 15 mins, 30 mins, 60 mins, after desufflation	—

Secondary

Measure	Time frame
To evaluate the impact of these three I:E ratios on gas exchange parameters and hemodynamic variables during pneumoperitoneum.Timepoint: 0 min, 15 mins, 30 mins, 60 mins, after desufflation	—

Countries

India

Contacts

Public ContactDr Ramya Ramesh

Vinayaka Missions Medical College and Hospital

ramyaramesh9831@gmail.com9526395712

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026