Health Condition 1: O034- Incomplete spontaneous abortion without complication
Conditions
Interventions
Intervention1: Letrozol: group 1 patient will take an oral dose of letrozole 10 mg once daily for three consecutive days in ward. On the morning of third dose. they will receive 800 mcg of vaginal mis
Sponsors
Dr Vandana Devi
Eligibility
Inclusion criteria
Inclusion criteria: 1.Hemodynamically stable patient 2.Gestational age up to 12 complete weeks of gestation by LMP and missed - abortion confirmed by following USG criteria [USG findings CRL more than 7mm and no heartbeat or mean sac diameter (MSD) more than 25 mm no embryo visualized] Hb 9 g/dl,
Exclusion criteria
Exclusion criteria: 1.Known hypersensitivity to letrozole or misoprostol, mifepristone 2.Known case of heart, liver, kidney disease and adrenal insufficiency 3.History of bleeding disorder or intake of anticoagulant drug 4.History of previous 2 LSCS or more, history of myomectomy or other uterine surgery 5.Diagnosed case of uterine fibroid, uterine anomalies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 9.To determine the efficacy of letrozole versus mifepristone as a pretreatment in management of first trimester missed abortion in terms of Induction to expulsion interval need for surgical interventions Timepoint: baseline follow by 2 week | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To evaluate and compare the following complications and side effects in both the groups a Abnormal uterine bleeding b Pain abdomen Retained product of conception after day 14 Timepoint: 14 days after expulsion | — |
Countries
India
Contacts
Public ContactDr Rashmi Khatri
Baba Saheb Ambedkar Hospital Rohini new Delhi
Outcome results
None listed