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In this trial I will compare nebulization with magnesium sulphate versus dexmedetomidine for controlling blood pressure spikes during securing airway in pregnant mothers with high blood pressure undergoing Caesarean section

Comparison of preoperative magnesium sulphate versus dexmedetomidine nebulisation for attenuation of hemodynamic response to laryngoscopy and endotracheal intubation in severe preeclampsia parturients undergoing caesarean section: A Randomised clinical study - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/09/094426
Enrollment
100
Registered
2025-09-08
Start date
Unknown
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O141- Severe pre-eclampsia

Interventions

Intervention1: Group D- Dexmedetomidine: With due approval from institutional ethical committee a randomised clinical study will be conducted on severe preeclampsia parturients undergoing caesarean s

Sponsors

JLN Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Parturients with severe preeclampsia undergoing caesarean section under general anaesthesia with asa physical status 1 and 2

Exclusion criteria

Exclusion criteria: 1)ASA status more than 2 2) Mallampati grade more than 2 3) Allergic to study drug 4) Anticipated difficult intubation 5) Requiring more than 2 attempts at intubation 6)BMI 40 or more than 40kg/m2 7) Comorbidities 8) Emergency Caesarean section 9) Consent not given to participate in clinical study

Design outcomes

Primary

MeasureTime frame
To assess changes in hemodynamic parameters like heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressureTimepoint: Assessed before nebulization, after completion of nebulization, at the time of laryngoscopy and intubation, at 1 min, 2min, 3min, 4min, 6min, 8min, 10min after intubation.

Secondary

MeasureTime frame
Cough at time of extubationTimepoint: At the time of extubation;Post operative sore throatTimepoint: At time of extubation, at 6hr post extubation and at 12hr post extubation;Side effects of drugTimepoint:

Countries

India

Contacts

Public ContactDr Arvind Khare

Jawahar lal Nehru Medical College

arvindkhare68@gmail.com9414306114

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026