A study to find out which of combination intravenous ketamine-propofol versus ketamine -dexmedetomidine in adult patient undergoing daycare procedure is better and safe. to see which drug combination gives better sedation, hemodynamic stabilty , less rescue bolus, and surgeon - patient satisfaction

To compare efficacy of intravenous ketamine-propofol versus ketamine -dexmedetomidine in adult patient undergoing daycare procedure - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/09/094392

Enrollment

100

Registered

2025-09-08

Start date

Unknown

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: intravenous infusion of ketamine - propofol: The study drugs will be prepared in 50-ml infusion syringes. The propofol infusion syringe contained 10 mg/ml propofol. Ketamine infusio

Eligibility

Inclusion criteria

Inclusion criteria: ASA Physical status I or II Scheduled for elective daycare procedure willing and able to provide written consent BMI between 18.5 to 29.9 Procedure duration less than 60 minutes

Exclusion criteria

Exclusion criteria: 1)known allergy to any of study drug 2)history of cardiovascular, hepatic, renal or psychiatric disorder 3)pregnancy or lactation 4)chronic use of sedative or opioids

Design outcomes

Primary

Measure	Time frame
1)To compare the demand of rescue anaesthetic during procedure. 2)2)To compare time require to achieve adequate and effective sedation for procedure ( Ramsay sedation score 5 ) between the study groups. Timepoint: Time from start of infusion to achieve RSS 5 ( ramsay sedation score ) from start of infusion , patient movement will be noted. if any movement is seen , that time will be documented.	—

Secondary

Measure	Time frame
) To compare the time to eye opening after cessation of infusion of study drugs between study groups. 2) To compare the recovery time between the two study groups 3)To compare the incidence of respiratory & airway-related complications between the two study groups 4) To assess & compare surgeon & patient satisfaction across both groups by using 3 point scale . Timepoint: time from stop of infusion till recovery. hemodynamice parameters will be notes at base line, 3 minutes 6 minutes 9 minutes 12 minutes 15 minutes 20 minutes 25 minutes 30 minutes 40 minutes 50 minutes 60 minutes	—

Measure

Time frame

) To compare the time to eye opening after cessation of infusion of study drugs between study groups. 2) To compare the recovery time between the two study groups 3)To compare the incidence of respiratory & airway-related complications between the two study groups 4) To assess & compare surgeon & patient satisfaction across both groups by using 3 point scale . Timepoint: time from stop of infusion till recovery. hemodynamice parameters will be notes at base line, 3 minutes 6 minutes 9 minutes 12 minutes 15 minutes 20 minutes 25 minutes 30 minutes 40 minutes 50 minutes 60 minutes

—

Countries

India

Contacts

Public ContactMehak

Adesh institute of medical science and research

upindermander01@gmail.com9815033776

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026