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Comparing the Effects of Magnesium and Fentanyl on Heart and Blood Pressure Responses During Nasal Intubation in Oral Cancer Surgery

Comparative study of effect of intravenous magnesium sulphate and fentanyl on hemodynamic responses to nasal intubation and laryngoscopy in oral cancer patients - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/09/094354
Enrollment
64
Registered
2025-09-08
Start date
Unknown
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C109- Malignant neoplasm of oropharynx,unspecified

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil

Sponsors

JNMC
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Age: 25 to 60 years. Diagnosed with oral cancer requiring elective surgery under general Anaesthesia with nasal intubation. ASA Physical Status: Classified as ASA III Informed Consent: written informed consent, in the case of minors or those unable to consent, consent obtained from their legal guardians. General Health: Patients with no contraindications for either magnesium sulphate or fentanyl administration. Planned Surgery: Patients scheduled for elective oral cancer surgery

Exclusion criteria

Exclusion criteria: Renal Impairment: Patients with renal insufficiency or chronic kidney disease (CKD), as magnesium sulphate may cause toxicity in those with impaired renal function. Respiratory Conditions: Patients with severe chronic obstructive pulmonary disease (COPD), asthma, or other significant pulmonary diseases Neurological Disorders: Patients with neuromuscular disorders (e.g., myasthenia gravis) that may be exacerbated by the NMDA receptor antagonist properties of magnesium sulphate. Allergic Reactions: Patients with a known allergy or hypersensitivity to magnesium sulphate, fentanyl, or any other opioids. Pregnancy or Lactation: or breastfeeding women

Design outcomes

Primary

MeasureTime frame
Intravenous magnesium sulphate will be more effective than fentanyl in providing sustained attenuation of hemodynamic responses (heart rate and blood pressure) during nasal intubation in oral cancer patients.Timepoint: 15 minutes—

Secondary

MeasureTime frame
1)To determine the duration of hemodynamic control offered by each drug following intubation. 2)To assess the need for additional pharmacological intervention in either group to maintain hemodynamic stability during or after intubation. 3)To evaluate patient outcomes and anaesthetic recovery characteristics, such as time to extubation or postoperative cardiovascular complications, if applicable.Timepoint: 15 minutes—

Countries

India

Contacts

Public ContactNeeta Chaudhary Verma

Datta Meghe Institute Of Medical Science And Research

neetachaudhary1234@gmail.com8788378382

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026