To compare efficacy of intravenous infusion of lidocaine with ketamine vs dexmedetomedine as opioid free anesthesia (OFA)

Perioperative Analgesic Efficacy of Intravenous Infusion of Lidocaine with Ketamine Vs Dexmedetomedine as Opioid Free Anaesthesia (OFA): A Randomised Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/09/094353

Enrollment

Registered

2025-09-08

Start date

Unknown

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Perioperative analgesic efficacy of opioid free anaesthesia using only intravenous infusion of lidocaine with ketamine vs dexmedetomedine: Comparing perioperative analgesic efficacy of

Eligibility

Inclusion criteria

Inclusion criteria: ASA Grade 1 and 2 Short to intermediate duration surgeries requiring general anaesthesia

Exclusion criteria

Exclusion criteria: Non consenting patients Patients less than 18yrs and more than 65yrs Patients allergic to local anaesthetics Prolonged duration of surgeries more than 2.5 hours

Design outcomes

Primary

Measure	Time frame
To study the effect of infusion of preservative free lidocaine given systemically on analgesic efficacy of infusions of ketamine vs dexmedetomidineTimepoint: T0- At incision baseline T1- 15 minutes T2- 30 minutes T3- 45 minutes T4- 60 minutes T5- 90 minutes T6- 120 minutes T7- 150 minutes	—

Secondary

Measure	Time frame
To study haemodynamic changes, side effects and complications of infusions of lidocaine added to infusions of ketamine and dexmedetomedineTimepoint: From incision during surgery under anaesthesia till post operative 24 hours	—

Countries

India

Contacts

Public ContactTania bansal

Adesh institute of medical sciences and research bhucho mandi bathinda

tania24073@gmail.com7888768873

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026