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Effect of Salmon Calcitonin Nasal Spray on Bone Healing After Wisdom Tooth Removal

Evaluation of the Efficacy of Intranasal Salmon Calcitonin on Bone Healing Following Surgical Removal of Impacted Mandibular Third Molars ? A Randomized Controlled Clinical Trial - NIL

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/09/094339
Enrollment
100
Registered
2025-09-08
Start date
Unknown
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K011- Impacted teeth

Interventions

Intervention1: Calcitonin Nasal Spray: Observing bone healing and analgesic effect of calcitonin hormone after third molar removal surgery for a total period of three months. Control Intervention1: Co

Sponsors

Harni N
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with impacted mandibular third molar. Pederson difficulty index score of 6 and above. Patients in the age group between 18 to 40 years ASA-1 category

Exclusion criteria

Exclusion criteria: Patients with seafood alleregy Patients with Peri apical pathology ASA-2,3,4,5 and 6 CATEGORIES Patient with any previous history of cardiomyopathy Patient with any known history of Thyroid dysfunction. Patient undergoing therapies with bisphosphonates and immunosuppressants. Patient with any known history of osteoporosis or pathologic fractures. Asthmatic patients.

Design outcomes

Primary

MeasureTime frame
A total of 100 patients will be randomly divided into two groups: Group I will receive intranasal salmon calcitonin along with standard postoperative care, while Group II will receive only standard care.Timepoint: Postoperative pain will be assessed using the Visual Analog Scale on days 1, 7, 14, 21, and 30.

Secondary

MeasureTime frame
bone healing will be evaluated by radiographic assessment of bone density at the extraction site immediately after surgery.Timepoint: Assessed at 4 weeks, and at 12 weeks.

Countries

India

Contacts

Public ContactHarni N

Madha Dental College

ch.satheesh@gmail.com9791048562

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026