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In women with uterine cancer whether the pre-test genetic counselling improves the genetic testing rate in patients and their relatives

Evaluation of impact of pre-test counselling on uptake of germline testing and assessment on barriers to genetic testing in women with endometrial cancer and her first-degree relatives - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/09/094258
Enrollment
100
Registered
2025-09-04
Start date
Unknown
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C541- Malignant neoplasm of endometrium

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil Intervention4: Nil: Nil Intervention5: Nil: Nil Intervention6: Nil: Nil Intervention7: Nil: Nil Intervention8: Nil: Nil Interven

Sponsors

AIIMS DELHI
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Women diagnosed with endometrial cancer having deficient mismatch repair (dMMR) on immuno-histochemistry (IHC). 2.Women diagnosed with endometrial cancer meeting the criteria for testing for Lynch Syndrome according to the NCCN criteria version 4.2024. 3. Women with endometrial cancer having an increased risk (more than or equal to 2.5 percent) of Lynch Syndrome as predicted by the PREMM5 risk prediction model. 4.Patients and first-degree relatives capable of providing informed consent.

Exclusion criteria

Exclusion criteria: 1.Women and first-degree relatives with diagnosed psychiatric illness currently under treatment 2.First-degree relatives with age less than 18years. 3.Not willing to participate.

Design outcomes

Primary

MeasureTime frame
?The proportion of women with endometrial cancer undergoing genetic counselling and, subsequently, germline testing. ?The proportion of first-degree relatives who are willing to undergo genetic counselling and subsequently agree to germline testing. ?The number of cases tested positive for Lynch-related mutations. ?The number of women who refuse to undergo genetic testing and the reasons for it. ?Number of FDRs who agree to undertake genetic counselling. ?Number of FDRs who undergo genetic testing after genetic counselling. Timepoint: 0 and 3months—

Secondary

MeasureTime frame
? Comparison of Stress, Anxiety, and Depression (DASS) 21 score at the time of genetic counselling and at 3 months of genetic counselling in women with endometrial cancer.Timepoint: 0 and 3months;? Evaluation of Satisfaction with the decision of the women with endometrial cancer at three months of genetic counselling by satisfaction with decision score (SWD score).Timepoint: 3month—

Countries

India

Contacts

Public ContactDr Rajesh Kumari

AIIMS DELHI

drrajeshkumari@yahoo.com1126588500

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026