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How preoperative frailty and muscle weakness affect memory and thinking after surgery in older patients

Preoperative frailty index and sarcopenia as predictors of postoperative cognitive dysfunction in elderly patients undergoing orthopedic surgery under spinal anaesthesia a prospective observational study. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/09/094238
Enrollment
115
Registered
2025-09-04
Start date
Unknown
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F05- Delirium due to known physiological condition

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil

Sponsors

Dr Divya S
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Scheduled to undergo elective orthopaedic surgery under spinal anaesthesia. 2.Age 65 years and above 3.Belonging to American society of Anesthesiologists (ASA) class I, II, III 4.Able to provide informed consent 5.Had a baseline Addenbrooke?s Cognitive Examination-III (ACE-III) score of more than 88

Exclusion criteria

Exclusion criteria: 1.Use of sedatives or conversion to general anaesthesia 2.Active alcohol abuse or chronic opioid/substance abuse 3.Pre-existing diagnosis of moderate to severe dementia or other major neurocognitive disorders. 4.History of psychiatric illness that may affect cognitive assessment (e.g., schizophrenia, major depression with psychosis). 5.Patients with neuromuscular disorders affecting hand grip strength (e.g., Parkinson?s disease, stroke with motor deficits).

Design outcomes

Primary

MeasureTime frame
Association between preoperative frailty measured by 5-factor Modified Frailty Index 5mFI and postoperative cognitive dysfunction.Timepoint: Association between preoperative frailty measured by 5-factor Modified Frailty Index 5mFI and postoperative cognitive dysfunction measured by ACE III preoperative baseline and 24 hours and 72 hours after surgery.—

Secondary

MeasureTime frame
Association between sarcopenia assessed by hand grip strength & post operative cognitive dysfunction.Timepoint: Association between sarcopenia assessed by hand digital dynamometer & postoperative cognitive dysfunction measured by ACE III preoperative baseline & 24 hours & 72 hours after surgery.—

Countries

India

Contacts

Public ContactDr Krishnaprabu R

Sri Venkateshwaraa Medical College Hospital and Research Centre

drkrishnaprabu@gmail.com9943770977

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026