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Efficacy of Ondansetron for the reduction of Propofol injection pain, A prospective Randomized Controlled Trial

Efficacy of Ondansetron with and without venous occlusion in the reduction of Propofol injection pain, A Double Blind Randomized Controlled Trial - NIL

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/09/094223
Enrollment
174
Registered
2025-09-04
Start date
Unknown
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Adult patients visiting AIIMS Gorakhpur scheduled for elective surgery under general anaesthesia with propofol induction who are found to be as per the inclusion criteria will be enroll

Sponsors

All India Institute of Medical Sciences Gorakhpur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged 18 - 60 years old, of either sex, physical status (ASA) I and II, who are scheduled for elective surgery under general anaesthesia with propofol induction with 20-gauge IV cannula at the dorsum of hand prior to surgery.

Exclusion criteria

Exclusion criteria: Patient refusal, Patients allergic to ondansetron, lignocaine or propofol,Patients who did not receive propofol for induction,Patients who used apomorphine, dronedarone, monoamine oxidase inhibitors and serotonergic drugs, Patients with cardiac arrhythmia like prolonged QT Syndrome or 2nd/3rd degree AV Block, Patients who had chronic pain , Patients who did not have 20G IV Cannula on the dorsum of the hand, Patients who received rapid sequence intubation technique.

Design outcomes

Primary

MeasureTime frame
Incidence of propofol injection pain in the three study groups. Timepoint: At the time of giving injection

Secondary

MeasureTime frame
Severity of propofol injection pain in the three study groups.Timepoint: till post operative 2 hours;Incidence of postoperative nausea & vomiting in the three study groups,Timepoint: till post operative 2 hours;Incidence of adverse effects, if any.Timepoint: till post operative 2 hours

Countries

India

Contacts

Public ContactPriyanka Dwivedi

AIIMS Gorakhpur

drpriyad1111@gmail.com08795453444

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026