Comparison of Dexamethasone and Clonidine added to local anaesthetic for pain relief in upper limb surgery using ultrasound-guided nerve block

Randomized double-blind controlled trial comparing the analgesic effect of Dexamethasone versus Clonidine as adjuvants to 0.5% Levobupivacaine in ultrasound-guided supraclavicular brachial plexus block in patients undergoing upper limb surgery at SMS Medical College, Jaipur.? - DEX-CLO LEVO

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/09/094211

Enrollment

Registered

2025-09-03

Start date

Unknown

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Levobupivacaine 0.5% (20 ml) + Dexamethasone 8 mg (2 ml): Levobupivacaine 0.5% (20 ml) with Dexamethasone 8 mg (2 ml), administered as single-shot ultrasound-guided supraclavicular brac

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status I or II Weight 50?80 kg Patients undergoing upper limb surgery under supraclavicular block Written informed consent provided

Exclusion criteria

Exclusion criteria: Allergy to study drugs (local anesthetic, dexamethasone, clonidine) Coagulopathy or anticoagulant therapy Local infection at injection site Psychiatric illness or anxiety Respiratory illness/compromise Peripheral neuropathy or suspected compartment syndrome Participation in another trial

Design outcomes

Primary

Measure	Time frame
Duration of analgesia: Time from block administration to first rescue analgesia (minutes)Timepoint: Continuously monitored postoperatively; recorded up to 24 hours after block	—

Secondary

Measure	Time frame
Onset of sensory blockTimepoint: Time Point: Assessed at 0, 2, 5, 10, 15, 20, and 30 minutes after block administration;Duration of sensory blockTimepoint: Monitored until regression; recorded up to 24 hours postoperatively;Onset of motor blockTimepoint: Assessed at 0, 10, 20, and 30 minutes after block administration;Duration of motor blockTimepoint: Monitored until regression; recorded up to 24 hours postoperatively;Adverse effectsTimepoint: Intraoperative and up to 24 hours postoperatively	—

Measure

Time frame

Onset of sensory blockTimepoint: Time Point: Assessed at 0, 2, 5, 10, 15, 20, and 30 minutes after block administration;Duration of sensory blockTimepoint: Monitored until regression; recorded up to 24 hours postoperatively;Onset of motor blockTimepoint: Assessed at 0, 10, 20, and 30 minutes after block administration;Duration of motor blockTimepoint: Monitored until regression; recorded up to 24 hours postoperatively;Adverse effectsTimepoint: Intraoperative and up to 24 hours postoperatively

—

Countries

India

Contacts

Public ContactDr Mamta Khandelwal

Department of Anaesthesiology and Critical Care, SMS Medical College & Attached Hospitals, Jaipur

drmamtakhandelwal@gmail.com9929338174

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026