A CBCT based clinical study of A-PRF plus and DFDBA in comparison to DFDBA alone in the management of human periodontal infrabony defect

A CBCT based clinical study on synergistic effects of A-PRF plus and DFDBA in comparison to DFDBA alone in the management of human periodontal infrabony defect: A split mouth randomized controlled trial - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/09/094197

Enrollment

Registered

2025-09-03

Start date

Unknown

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: DFDBA AND A-PRF+: DFDBA(Demineralised freezed dried bone allograft)- it is a type bone graft. A-PRF Plus(Advanced Platelet Rich Fibrin Plus)-it is new generation of prf. It will be used

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age: 18-55 years old 2. Patients with clinical evidence of periodontal pocket with probing depths more than 5mm. 3. Having radiographic evidence of bilateral vertical bone loss in the posterior teeth. 4. Patients with good general health, without any history of systemic disease or compromising medical conditions.

Exclusion criteria

Exclusion criteria: 1. Patients having unacceptable oral hygiene during pre-surgical phase (phase I) period. 2. History of antibiotics or other medications affecting the periodontium, within the previous six months. 3. Patients who have received periodontal treatment in the past 6 months. 4. Smokers or use of tobacco. 5. Pregnant women and lactating mothers. 6. Uncooperative patients.

Design outcomes

Primary

Measure	Time frame
1.To evaluate the efficacy of A PRF+ and DFDBA in management of human infrabony defects. 2.To evaluate efficacy of DFDBA alone in management of human infrabony defects. 3.To evaluate and compare radiographically the bone fill obtained by A-PRF+ with DFDBA and DFDBA alone. Timepoint: Baseline 6months and 9months	—

Secondary

Measure	Time frame
To evaluate the clinical outcomes of A-PRF+ with DFDBA and DFDBA aloneTimepoint: Baseline 6months and 9months	—

Countries

India

Contacts

Public ContactDR AISHWARYA NALWAD

SDM university of dental science college and hospital.

goswamymonika@gmail.com9929796568

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026