Health Condition 1: K053- Chronic periodontitis Health Condition 2: K088- Other specified disorders of teethand supporting structures
Conditions
Interventions
Intervention1: Doxycycline + Guided Tissue Regeneration (GTR with xenograft and resorbable membrane): Preoperative subgingival application of locally delivered doxycycline gel into the periodontal poc
Sponsors
Dr Athul krishna P
Eligibility
Inclusion criteria
Inclusion criteria: Patients aged between 25 years and 60 years. Both male and female patients. Patients diagnosed with Stage III or Stage IV periodontitis with two-walled or three-walled infrabony defects, or mandibular molar Class II furcation defects. Full mouth plaque score and full mouth bleeding score less than 15 percent at the time of enrollment. At least one tooth with probing pocket depth more than or equal to 6 millimeters with the above mentioned defects. Patients willing to undergo surgical intervention and attend follow up visits
Exclusion criteria
Exclusion criteria: Patients with known allergy to doxycycline or other drugs in the same class. Smokers who consume more than ten cigarettes per day. Patients with uncontrolled diabetes that may affect periodontal healing. Pregnant or lactating women. Patients with a history of periodontal surgery in the last twelve months at the same site. Patients with poor plaque control despite oral hygiene instructions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical attachment level gain at six months post surgeryTimepoint: 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in probing pocket depthTimepoint: Baseline and 6 months post surgery;Change in gingival recessionTimepoint: Baseline and 6 months post surgery ; Change in bleeding on probing score Timepoint: Baseline and 6 months post surgery;Radiographic bone fill Timepoint: Baseline and 6 months post surgery;Change in defect angle Timepoint: Baseline and 6 months post surgery;Early wound healing index Timepoint: 1 week post surgery;Post operative discomfort assessed by visual analogue scale Timepoint: 1 week post surgery;Change in Porphyromonas gingivalis load assessed by real time PCR Timepoint: Baseline and 1 month post surgery | — |
Countries
India
Contacts
Public ContactDr BAIJU RM
GOVERNMENT DENTAL COLLEGE KOTTAYAM
Outcome results
None listed