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Scaling and Root Planing Improves Key Inflammatory Markers in Patients with Metabolic Syndrome and Periodontitis

Efficacy of scaling and root planing on salivary leptin and interleukin 6 levels in patients with metabolic syndrome and periodontitis - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/09/094164
Enrollment
40
Registered
2025-09-03
Start date
Unknown
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E116- Type 2 diabetes mellitus with other specified complications

Interventions

Intervention1: Scaling and root planing in patients with metabolic syndrome: Scaling and root planing of the patients with metabolic syndome will be done. Baseline salivary samples and samples after 3

Sponsors

Sohail Ahmed
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ?Patients aged between 35-60 years. ?Patients with chronic periodontitis only (bleeding on probing present). ?Probing pocket depth more than 5 mm. ?Clinical attachment loss more than 3 mm. ?Periodontitis patients with metabolic syndrome as per the criteria of the International Diabetes Federation (IDF). IDF criteria for metabolic syndrome: The International Diabetes Federation (IDF) defines metabolic syndrome as the presence of central obesity and at least two of the following four factors: 1. Triglycerides: Raised levels of triglycerides, defined as at least 150 mg/dL 2. HDL cholesterol: Reduced levels of HDL cholesterol, defined as less than 40 mg dL for men and less than 50 mg dL for women 3. Blood pressure: Raised blood pressure, defined as at least 130/85 mm Hg 4. Fasting plasma glucose: Raised levels of fasting plasma glucose, defined as at least 100 mg/dL

Exclusion criteria

Exclusion criteria: ?Pregnancy or lactation. ?Use of antibiotics or anti-inflammatory drugs in the last 3 months. ?Smokers or alcohol consumers with known addiction. ?Any systemic inflammatory or autoimmune diseases.

Design outcomes

Primary

MeasureTime frame
Will the salivary leptin and interleukin-6 (IL-6) levels will be decreased three months after scaling and root planning?Timepoint: Baseline and 3 months—

Secondary

MeasureTime frame
Clinical parameters- Plaque index, Probing pocket depth and Clinical attachment levels will be assessed using Williams Probe at baseline and three months after scaling and root planing.Timepoint: baseline and 3 months—

Countries

India

Contacts

Public ContactSohail Ahmed

Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre

veerureddy@yahoo.com9866199902

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026