Effect of early high frequency ventilation on death in children with acute lung disease

Early vs Conventional High-Frequency Oscillatory Ventilation in Moderate and Severe Acute Respiratory Distress syndrome: An Open Labelled Randomized Superiority Controlled Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/09/094156

Enrollment

Registered

2025-09-03

Start date

Unknown

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J960- Acute respiratory failure

Interventions

Intervention1: Early high frequency oscillatory ventilation, a modality of invasive ventilation: Children diagnosed with moderate or severe acute respiratory distress syndrome are upfront initiated on

Eligibility

Inclusion criteria

Inclusion criteria: Children aged 1 month to 14 years admitted in PICU, with moderate and severe ARDS classified as per PALICC 1 guidelines.

Exclusion criteria

Exclusion criteria: 1. History of interstitial lung disease 2. Chronic renal failure 3. Central nervous system involvement: Especially raised intracranial pressure 4. Immunodeficient patients including malignancy and post marrow transplant recipients 5. Post cardiac surgery patients 6. Consent denial

Design outcomes

Primary

Measure	Time frame
To compare 28-day mortality outcomes between early HFOV group and conventional/ rescue HFOV group.Timepoint: To compare 28-day mortality outcomes between early HFOV group and conventional/ rescue HFOV group.	—

Secondary

Measure	Time frame
To determine the time taken for improvement in oxygenation and ventilatory parameters, duration of ventilation and length of ICU stay.Timepoint: Till patient is in ICU	—

Countries

India

Contacts

Public ContactSathwik Gangireddy

All India Institute of Medical Sciences, Raipur

drmrsahoo@gmail.com9786722877

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026