Health Condition 1: C509- Malignant neoplasm of breast of unspecified site
Conditions
Interventions
Intervention1: Modified Radiotherapy Plan: Modified Radiotherapy plan using information obtained by SPECT/Lymphoscintigraphy scan in early breast cancer patients followed by 6 months of follow up
Cont
Sponsors
Jawaharlal Institute of Postgraduate Medical Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: 1.Unilateral Breast cancer 2.Post breast conservation surgery 3.Adequate axillary lymphnode dissection(atleast 10 nodes dissected) 4.Clinically T1/2 N0/1M0, Patients planned only for whole-breast radiation with or without tumour bed boost and Either post upfront surgery and Margins free a. Pathologically N0 disease and ALND Negative b. SLNB positive (1-2) with ALND negative with no high-risk features c. pN1with 1-2 nodes positive with no high-risk features (high-risk features such as Lymphovascular space invasion or extra nodal extension or Grade 3 or pT2 with Hormone receptor negative) Or post-NACT (NACT given due to delay in surgery/ TNBC) d. cT1/2N0 with ypT1/2N0 on ALND 5.Postive SPECT scan uptake in the arm draining lymph node 6.Dose constraints to arm draining node is acheived without compromising on the already set target volume coverage and constraints to normal OAR
Exclusion criteria
Exclusion criteria: 1. Bilateral breast cancer/ recurrent breast cancer 2. Previous radiation therapy to chest wall 3. Active infection in local site, i.e., arm. 4. Predisposing conditions to Lymphedema and lymphadenitis 5. Pregnancy and lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Modified RT plan reduces the incidence of lymphedema compared to the standard RT plan by limiting the incidental unplanned radiation dose to SPECT/CT identified arm draining lymph node/s/ region.Timepoint: at 6 months post-radiotherapy | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.comparison of the quality of life (LyQLI) score between the two arms at baseline and at 6 months post radiotherapy 2.comparison of the incidence of lymphedema (any grade) between the two arms at 1 year and 3 years post radiotherapy 3.comparison of any local or regional nodal or distant recurrence between 2 arms at 6 months, 1 year and 3 years post radiotherapy Timepoint: 6 months, 1 year and 3 years | — |
Countries
India
Contacts
Public ContactDr Gunaseelan K
Department of Radiation oncology, Regional cancer centre, Jawaharlal Institute of Postgraduate Medical Education & Research,
Outcome results
None listed